Inside Cover: Introduction of d-Glutamate at a Critical Residue of A[beta]42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity

Learning by looking into a mirror, using a variant of the Alzheimer's amyloid beta42 peptide (E22e variant) with a d-amino acid introduced at the glutamate residue22. Although low-n oligomers were unaffected, a soluble ordered intermediate unique to the E22e variant was identified, with a marke...

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Veröffentlicht in:	Chemistry : a European journal 2016-08, Vol.22 (34), p.11874
Hauptverfasser:	Warner, Christopher J A, Dutta, Subrata, Foley, Alejandro R, Raskatov, Jevgenij A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino acids Chemistry Cytotoxicity Neurodegenerative diseases Oligomers Toxic diseases Toxicity β-Amyloid
Online-Zugang:	Volltext
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