Inside Cover: Introduction of d-Glutamate at a Critical Residue of A[beta]42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity

Learning by looking into a mirror, using a variant of the Alzheimer's amyloid beta42 peptide (E22e variant) with a d-amino acid introduced at the glutamate residue22. Although low-n oligomers were unaffected, a soluble ordered intermediate unique to the E22e variant was identified, with a marke...

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Veröffentlicht in:	Chemistry : a European journal 2016-08, Vol.22 (34), p.11874
Hauptverfasser:	Warner, Christopher J A, Dutta, Subrata, Foley, Alejandro R, Raskatov, Jevgenij A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino acids Chemistry Cytotoxicity Neurodegenerative diseases Oligomers Toxic diseases Toxicity β-Amyloid
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description	Learning by looking into a mirror, using a variant of the Alzheimer's amyloid beta42 peptide (E22e variant) with a d-amino acid introduced at the glutamate residue22. Although low-n oligomers were unaffected, a soluble ordered intermediate unique to the E22e variant was identified, with a marked enhancement in the cytotoxicity against neuron-like model cells. This study could help to deepen our understanding of the amyloid beta toxicity in Alzheimer's disease. More information can be found in the Communication by J.A.Raskatov et al. on page11967ff.
doi_str_mv	10.1002/chem.201603417
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subjects	Alzheimer's disease Amino acids Chemistry Cytotoxicity Neurodegenerative diseases Oligomers Toxic diseases Toxicity β-Amyloid
title	Inside Cover: Introduction of d-Glutamate at a Critical Residue of A[beta]42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity
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