Targeting Immunotherapy to the Tumor Microenvironment

ABSTRACT Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus...

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Veröffentlicht in:Journal of cellular biochemistry 2017-10, Vol.118 (10), p.3049-3054
Hauptverfasser: Dougan, Michael, Dougan, Stephanie K.
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Dougan, Stephanie K.
description ABSTRACT Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus on the principles of in situ vaccination. Certain types of therapies are more amenable to local versus systemic delivery; these include cytokines, adjuvants, radiation, and agents targeting tumor‐resident cell populations. Several approaches for targeting the tumor microenvironment are under development. Nanoparticles, peptide or antibody‐based delivery, and exploitation of cellular influx are all promising ways to delivery immune modulating compounds to tumors. J. Cell. Biochem. 118: 3049–3054, 2017. © 2017 Wiley Periodicals, Inc. Immune modulating agents that increase activation of local dendritic cells loaded with tumor material will enhance T cell priming and be highly effective therapeutics. These agents must be delivered to the tumor microenvironment via strategies discussed in this review.
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How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus on the principles of in situ vaccination. Certain types of therapies are more amenable to local versus systemic delivery; these include cytokines, adjuvants, radiation, and agents targeting tumor‐resident cell populations. Several approaches for targeting the tumor microenvironment are under development. Nanoparticles, peptide or antibody‐based delivery, and exploitation of cellular influx are all promising ways to delivery immune modulating compounds to tumors. J. Cell. Biochem. 118: 3049–3054, 2017. © 2017 Wiley Periodicals, Inc. Immune modulating agents that increase activation of local dendritic cells loaded with tumor material will enhance T cell priming and be highly effective therapeutics. 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subjects Adjuvants
Animals
Antineoplastic Agents - therapeutic use
Cancer
CANCER IMMUNOLOGY
Cytokines
Drug delivery
Drug Delivery Systems - methods
DRUG TARGETING
Drugs
Exploitation
Humans
Immunology
Immunosuppressive agents
IMMUNOTHERAPY
Nanoparticles
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Radiation
Toxicity
TUMOR MICROENVIRONMENT
Tumor Microenvironment - drug effects
Tumors
Vaccination
title Targeting Immunotherapy to the Tumor Microenvironment
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