Targeting Immunotherapy to the Tumor Microenvironment
ABSTRACT Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus...
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Veröffentlicht in: | Journal of cellular biochemistry 2017-10, Vol.118 (10), p.3049-3054 |
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description | ABSTRACT
Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus on the principles of in situ vaccination. Certain types of therapies are more amenable to local versus systemic delivery; these include cytokines, adjuvants, radiation, and agents targeting tumor‐resident cell populations. Several approaches for targeting the tumor microenvironment are under development. Nanoparticles, peptide or antibody‐based delivery, and exploitation of cellular influx are all promising ways to delivery immune modulating compounds to tumors. J. Cell. Biochem. 118: 3049–3054, 2017. © 2017 Wiley Periodicals, Inc.
Immune modulating agents that increase activation of local dendritic cells loaded with tumor material will enhance T cell priming and be highly effective therapeutics. These agents must be delivered to the tumor microenvironment via strategies discussed in this review. |
doi_str_mv | 10.1002/jcb.26005 |
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Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus on the principles of in situ vaccination. Certain types of therapies are more amenable to local versus systemic delivery; these include cytokines, adjuvants, radiation, and agents targeting tumor‐resident cell populations. Several approaches for targeting the tumor microenvironment are under development. Nanoparticles, peptide or antibody‐based delivery, and exploitation of cellular influx are all promising ways to delivery immune modulating compounds to tumors. J. Cell. Biochem. 118: 3049–3054, 2017. © 2017 Wiley Periodicals, Inc.
Immune modulating agents that increase activation of local dendritic cells loaded with tumor material will enhance T cell priming and be highly effective therapeutics. These agents must be delivered to the tumor microenvironment via strategies discussed in this review.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.26005</identifier><identifier>PMID: 28332219</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adjuvants ; Animals ; Antineoplastic Agents - therapeutic use ; Cancer ; CANCER IMMUNOLOGY ; Cytokines ; Drug delivery ; Drug Delivery Systems - methods ; DRUG TARGETING ; Drugs ; Exploitation ; Humans ; Immunology ; Immunosuppressive agents ; IMMUNOTHERAPY ; Nanoparticles ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Neoplasms - pathology ; Radiation ; Toxicity ; TUMOR MICROENVIRONMENT ; Tumor Microenvironment - drug effects ; Tumors ; Vaccination</subject><ispartof>Journal of cellular biochemistry, 2017-10, Vol.118 (10), p.3049-3054</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-8d0ecfe1c72022bff3657088a2ce0ccf3316ac10c23dca44383205c3f1be53eb3</citedby><cites>FETCH-LOGICAL-c3535-8d0ecfe1c72022bff3657088a2ce0ccf3316ac10c23dca44383205c3f1be53eb3</cites><orcidid>0000-0002-2263-363X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.26005$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.26005$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28332219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dougan, Michael</creatorcontrib><creatorcontrib>Dougan, Stephanie K.</creatorcontrib><title>Targeting Immunotherapy to the Tumor Microenvironment</title><title>Journal of cellular biochemistry</title><addtitle>J Cell Biochem</addtitle><description>ABSTRACT
Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus on the principles of in situ vaccination. Certain types of therapies are more amenable to local versus systemic delivery; these include cytokines, adjuvants, radiation, and agents targeting tumor‐resident cell populations. Several approaches for targeting the tumor microenvironment are under development. Nanoparticles, peptide or antibody‐based delivery, and exploitation of cellular influx are all promising ways to delivery immune modulating compounds to tumors. J. Cell. Biochem. 118: 3049–3054, 2017. © 2017 Wiley Periodicals, Inc.
Immune modulating agents that increase activation of local dendritic cells loaded with tumor material will enhance T cell priming and be highly effective therapeutics. These agents must be delivered to the tumor microenvironment via strategies discussed in this review.</description><subject>Adjuvants</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cancer</subject><subject>CANCER IMMUNOLOGY</subject><subject>Cytokines</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>DRUG TARGETING</subject><subject>Drugs</subject><subject>Exploitation</subject><subject>Humans</subject><subject>Immunology</subject><subject>Immunosuppressive agents</subject><subject>IMMUNOTHERAPY</subject><subject>Nanoparticles</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Radiation</subject><subject>Toxicity</subject><subject>TUMOR MICROENVIRONMENT</subject><subject>Tumor Microenvironment - drug effects</subject><subject>Tumors</subject><subject>Vaccination</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQQC0EoqUw8AdQJCaGtOe7OB8jVHwUFbGU2XJcu6RqkuIkRf33GFLYmO6Gp3enx9glhzEHwMla52OMAcQRG3LIkjCKo-iYDSEhCJE4DthZ06wBIMsIT9kAUyJEng2ZWCi3Mm1RrYJZWXZV3b4bp7b7oK0DvwaLrqxd8FJoV5tqV7i6Kk3VnrMTqzaNuTjMEXt7uF9Mn8L56-NsejsPNQkSYboEo63hOkFAzK2lWCSQpgq1Aa0tEY-V5qCRllpFEaWEIDRZnhtBJqcRu-69W1d_dKZp5bruXOVPSp5hwtOIx4mnbnrKP9k0zli5dUWp3F5ykN-BpA8kfwJ59upg7PLSLP_I3yIemPTAZ7Ex-_9N8nl61yu_AO1cbmE</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Dougan, Michael</creator><creator>Dougan, Stephanie K.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-2263-363X</orcidid></search><sort><creationdate>201710</creationdate><title>Targeting Immunotherapy to the Tumor Microenvironment</title><author>Dougan, Michael ; Dougan, Stephanie K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-8d0ecfe1c72022bff3657088a2ce0ccf3316ac10c23dca44383205c3f1be53eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adjuvants</topic><topic>Animals</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cancer</topic><topic>CANCER IMMUNOLOGY</topic><topic>Cytokines</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems - methods</topic><topic>DRUG TARGETING</topic><topic>Drugs</topic><topic>Exploitation</topic><topic>Humans</topic><topic>Immunology</topic><topic>Immunosuppressive agents</topic><topic>IMMUNOTHERAPY</topic><topic>Nanoparticles</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Radiation</topic><topic>Toxicity</topic><topic>TUMOR MICROENVIRONMENT</topic><topic>Tumor Microenvironment - drug effects</topic><topic>Tumors</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dougan, Michael</creatorcontrib><creatorcontrib>Dougan, Stephanie K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dougan, Michael</au><au>Dougan, Stephanie K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting Immunotherapy to the Tumor Microenvironment</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J Cell Biochem</addtitle><date>2017-10</date><risdate>2017</risdate><volume>118</volume><issue>10</issue><spage>3049</spage><epage>3054</epage><pages>3049-3054</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>ABSTRACT
Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune‐based therapies is less clear. In this review, we explain the immunology of cancer, with a focus on the principles of in situ vaccination. Certain types of therapies are more amenable to local versus systemic delivery; these include cytokines, adjuvants, radiation, and agents targeting tumor‐resident cell populations. Several approaches for targeting the tumor microenvironment are under development. Nanoparticles, peptide or antibody‐based delivery, and exploitation of cellular influx are all promising ways to delivery immune modulating compounds to tumors. J. Cell. Biochem. 118: 3049–3054, 2017. © 2017 Wiley Periodicals, Inc.
Immune modulating agents that increase activation of local dendritic cells loaded with tumor material will enhance T cell priming and be highly effective therapeutics. These agents must be delivered to the tumor microenvironment via strategies discussed in this review.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28332219</pmid><doi>10.1002/jcb.26005</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2263-363X</orcidid></addata></record> |
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subjects | Adjuvants Animals Antineoplastic Agents - therapeutic use Cancer CANCER IMMUNOLOGY Cytokines Drug delivery Drug Delivery Systems - methods DRUG TARGETING Drugs Exploitation Humans Immunology Immunosuppressive agents IMMUNOTHERAPY Nanoparticles Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Radiation Toxicity TUMOR MICROENVIRONMENT Tumor Microenvironment - drug effects Tumors Vaccination |
title | Targeting Immunotherapy to the Tumor Microenvironment |
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