Super‐macroporous dextran cryogels via UV‐induced crosslinking: synthesis and characterization
Cryogenic treatment and UV irradiation were exploited for the preparation of super‐macroporous cryogels from non‐modified high‐molar‐mass dextran. The photo‐crosslinking process was initiated by (4‐benzoylbenzyl)trimethylammonium chloride and N,N′‐methylenebisacrylamide (BAAm) was used as a crosslin...
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| Veröffentlicht in: | Polymer international 2017-09, Vol.66 (9), p.1306-1311 |
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| creator | Georgiev, Georgy L Trzebicka, Barbara Kostova, Bistra Petrov, Petar D |
| description | Cryogenic treatment and UV irradiation were exploited for the preparation of super‐macroporous cryogels from non‐modified high‐molar‐mass dextran. The photo‐crosslinking process was initiated by (4‐benzoylbenzyl)trimethylammonium chloride and N,N′‐methylenebisacrylamide (BAAm) was used as a crosslinking agent. Gel fraction yield and degree of swelling of the dextran cryogels were determined gravimetrically. Cryogel morphology and mechanical properties were studied using environmental scanning electron microscopy and dynamic rheological measurements, respectively. The effects of dextran concentration in the initial polymer solution, polymer molar mass and BAAm content on the crosslinking efficacy, physico‐mechanical properties and morphology of the cryogels were evaluated. The dextran cryogels were assessed as carriers of the model water‐soluble drug metoprolol. © 2017 Society of Chemical Industry
Dextran cryogels were successfully synthesized by photochemical crosslinking of a non‐modified high‐molar‐mass linear precursor in a frozen aqueous system. |
| doi_str_mv | 10.1002/pi.5386 |
| format | Article |
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Dextran cryogels were successfully synthesized by photochemical crosslinking of a non‐modified high‐molar‐mass linear precursor in a frozen aqueous system.</description><identifier>ISSN: 0959-8103</identifier><identifier>EISSN: 1097-0126</identifier><identifier>DOI: 10.1002/pi.5386</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Chloride ; Crosslinking ; cryogels ; Cryogenic treatment ; Dextran ; drug delivery ; Electron microscopy ; Gravimetry ; Mechanical properties ; Methylene bisacrylamide ; Metoprolol ; Morphology ; Rheological properties ; Scanning electron microscopy ; Trimethylammonium chloride ; Ultraviolet radiation ; UV‐induced crosslinking</subject><ispartof>Polymer international, 2017-09, Vol.66 (9), p.1306-1311</ispartof><rights>2017 Society of Chemical Industry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2576-90b593bd24383e2d24144e96046eefa724730f19b8c9c69cf5d3b6e626b61c0d3</citedby><orcidid>0000-0002-5777-2066</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpi.5386$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpi.5386$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Georgiev, Georgy L</creatorcontrib><creatorcontrib>Trzebicka, Barbara</creatorcontrib><creatorcontrib>Kostova, Bistra</creatorcontrib><creatorcontrib>Petrov, Petar D</creatorcontrib><title>Super‐macroporous dextran cryogels via UV‐induced crosslinking: synthesis and characterization</title><title>Polymer international</title><description>Cryogenic treatment and UV irradiation were exploited for the preparation of super‐macroporous cryogels from non‐modified high‐molar‐mass dextran. The photo‐crosslinking process was initiated by (4‐benzoylbenzyl)trimethylammonium chloride and N,N′‐methylenebisacrylamide (BAAm) was used as a crosslinking agent. Gel fraction yield and degree of swelling of the dextran cryogels were determined gravimetrically. Cryogel morphology and mechanical properties were studied using environmental scanning electron microscopy and dynamic rheological measurements, respectively. The effects of dextran concentration in the initial polymer solution, polymer molar mass and BAAm content on the crosslinking efficacy, physico‐mechanical properties and morphology of the cryogels were evaluated. The dextran cryogels were assessed as carriers of the model water‐soluble drug metoprolol. © 2017 Society of Chemical Industry
Dextran cryogels were successfully synthesized by photochemical crosslinking of a non‐modified high‐molar‐mass linear precursor in a frozen aqueous system.</description><subject>Chloride</subject><subject>Crosslinking</subject><subject>cryogels</subject><subject>Cryogenic treatment</subject><subject>Dextran</subject><subject>drug delivery</subject><subject>Electron microscopy</subject><subject>Gravimetry</subject><subject>Mechanical properties</subject><subject>Methylene bisacrylamide</subject><subject>Metoprolol</subject><subject>Morphology</subject><subject>Rheological properties</subject><subject>Scanning electron microscopy</subject><subject>Trimethylammonium chloride</subject><subject>Ultraviolet radiation</subject><subject>UV‐induced crosslinking</subject><issn>0959-8103</issn><issn>1097-0126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNotkNFKwzAYhYMoOKf4CgUvpfNP0qaNdzKcDgYKOm9DmqZbZpfUpFXrlY_gM_okdsyr7-J8nAMHoXMMEwxArhozSWnODtAIA89iwIQdohHwlMc5BnqMTkLYAEDOOR-h4qlrtP_9_tlK5V3jvOtCVOrP1ksbKd-7la5D9G5ktHwZLGPLTulySFwItbGvxq6uo9Dbdq2DCZG0Q7aWXqpWe_MlW-PsKTqqZB302T_HaDm7fZ7ex4uHu_n0ZhErkmYs5lCknBYlSWhONRmIk0RzBgnTupIZSTIKFeZFrrhiXFVpSQumGWEFwwpKOkYX-97Gu7dOh1ZsXOftMCkwJxnGjKR4sC731oepdS8ab7bS9wKD2L0nGiN274nH-Q70D3_LZrg</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Georgiev, Georgy L</creator><creator>Trzebicka, Barbara</creator><creator>Kostova, Bistra</creator><creator>Petrov, Petar D</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>7SR</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-5777-2066</orcidid></search><sort><creationdate>201709</creationdate><title>Super‐macroporous dextran cryogels via UV‐induced crosslinking: synthesis and characterization</title><author>Georgiev, Georgy L ; Trzebicka, Barbara ; Kostova, Bistra ; Petrov, Petar D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2576-90b593bd24383e2d24144e96046eefa724730f19b8c9c69cf5d3b6e626b61c0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Chloride</topic><topic>Crosslinking</topic><topic>cryogels</topic><topic>Cryogenic treatment</topic><topic>Dextran</topic><topic>drug delivery</topic><topic>Electron microscopy</topic><topic>Gravimetry</topic><topic>Mechanical properties</topic><topic>Methylene bisacrylamide</topic><topic>Metoprolol</topic><topic>Morphology</topic><topic>Rheological properties</topic><topic>Scanning electron microscopy</topic><topic>Trimethylammonium chloride</topic><topic>Ultraviolet radiation</topic><topic>UV‐induced crosslinking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Georgiev, Georgy L</creatorcontrib><creatorcontrib>Trzebicka, Barbara</creatorcontrib><creatorcontrib>Kostova, Bistra</creatorcontrib><creatorcontrib>Petrov, Petar D</creatorcontrib><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymer international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Georgiev, Georgy L</au><au>Trzebicka, Barbara</au><au>Kostova, Bistra</au><au>Petrov, Petar D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Super‐macroporous dextran cryogels via UV‐induced crosslinking: synthesis and characterization</atitle><jtitle>Polymer international</jtitle><date>2017-09</date><risdate>2017</risdate><volume>66</volume><issue>9</issue><spage>1306</spage><epage>1311</epage><pages>1306-1311</pages><issn>0959-8103</issn><eissn>1097-0126</eissn><abstract>Cryogenic treatment and UV irradiation were exploited for the preparation of super‐macroporous cryogels from non‐modified high‐molar‐mass dextran. The photo‐crosslinking process was initiated by (4‐benzoylbenzyl)trimethylammonium chloride and N,N′‐methylenebisacrylamide (BAAm) was used as a crosslinking agent. Gel fraction yield and degree of swelling of the dextran cryogels were determined gravimetrically. Cryogel morphology and mechanical properties were studied using environmental scanning electron microscopy and dynamic rheological measurements, respectively. The effects of dextran concentration in the initial polymer solution, polymer molar mass and BAAm content on the crosslinking efficacy, physico‐mechanical properties and morphology of the cryogels were evaluated. The dextran cryogels were assessed as carriers of the model water‐soluble drug metoprolol. © 2017 Society of Chemical Industry
Dextran cryogels were successfully synthesized by photochemical crosslinking of a non‐modified high‐molar‐mass linear precursor in a frozen aqueous system.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/pi.5386</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5777-2066</orcidid></addata></record> |
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| identifier | ISSN: 0959-8103 |
| ispartof | Polymer international, 2017-09, Vol.66 (9), p.1306-1311 |
| issn | 0959-8103 1097-0126 |
| language | eng |
| recordid | cdi_proquest_journals_1927116251 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Chloride Crosslinking cryogels Cryogenic treatment Dextran drug delivery Electron microscopy Gravimetry Mechanical properties Methylene bisacrylamide Metoprolol Morphology Rheological properties Scanning electron microscopy Trimethylammonium chloride Ultraviolet radiation UV‐induced crosslinking |
| title | Super‐macroporous dextran cryogels via UV‐induced crosslinking: synthesis and characterization |
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