Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells

Triple negative breast cancer (TNBC) is an aggressive cancer for which prognosis remains poor. Combination therapy is a promising strategy for enhancing treatment efficacy. Blockade of STAT3 signaling may enhance the response of cancer cells to conventional chemotherapeutic agents. Here we used a SH...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2017-09, Vol.95 (9), p.965-975
Hauptverfasser:	Liu, Chun-Yu, Chen, Kuen-Feng, Chao, Tzu-I, Chu, Pei-Yi, Huang, Chun-Teng, Huang, Tzu-Ting, Yang, Hsiu-Ping, Wang, Wan-Lun, Lee, Chia-Han, Lau, Ka-Yi, Tsai, Wen-Chun, Su, Jung-Chen, Wu, Chia-Yun, Chen, Ming-Huang, Shiau, Chung-Wai, Tseng, Ling-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Breast cancer Cell Line, Tumor Cell lines Cell Proliferation - drug effects Chemotherapy Cyclin D1 Cytotoxicity Disease Models, Animal Docetaxel Drug Synergism Ectopic expression Female Gene expression Gene Expression Regulation, Neoplastic GLP-1 receptor agonists Growth inhibition Human Genetics Humans Inhibition Internal Medicine Medical prognosis Mice Molecular Medicine Mutants Original Article Phenyl Ethers - pharmacology Phenylurea Compounds - pharmacology Prognosis Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism SHP-1 protein Signal Transduction - drug effects siRNA Stat3 protein STAT3 Transcription Factor - metabolism Survival Taxoids - pharmacology Transcription, Genetic Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - mortality Xenograft Model Antitumor Assays Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!