D108 CELL FATE DECISIONS: SENESCENCE, REPAIR, AND REGENERATION: Modeling Zaat-Driven Proteotoxicity Using Crispr-Edited Syngeneic Patient-Ipscs

Following successful targeting of the Z mutation we have demonstrated the resultant isogenic iPSCs lose the pathognomonic AAT protein retention, which is associated with significant changes in gene expression. Analysis of the gene expression signature resulting from correction of iPSCs derived from...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser:	Kaserman, J, Estevez, F Molina, Higgins, M, Mostoslavsky, G, Kotton, D N, Wilson, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics CRISPR Gene expression Liver diseases Mutation Patients Proteins
Online-Zugang:	Volltext
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