D21 IMMUNE PATHWAYS IN ACUTE LUNG INJURY AND FIBROSIS: Novel Non-Catalytic Substrate-Selective P38α-Specific Mapk Inhibitors With Endothelial-Stabilizing And Anti-Inflammatory Activity That Mitigates Experimental Acute Lung Injury

Background: p38 MAPK signaling is important in regulating lung inflammation and injury, but the currently available p38 catalytic inhibitors (e.g. SB203580), which target the kinase active site, were poorly effective and caused toxicity in clinical trials. Methods: We used CADD to search a 60,000 co...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser:	Shah, N G, Tulapurkar, M, Ramarathnam, A, Hom, K, Martinez, R, Singh, I, MacKerell, A, Shapiro, P, Hasday, J D
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene expression Kinases Rodents
Online-Zugang:	Volltext
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