D108 CELL FATE DECISIONS: SENESCENCE, REPAIR, AND REGENERATION: Activation Of The Mtor Pathway Drives Lung Cell Senescence And Emphysema In Chronic Obstructive Pulmonary Disease (COPD)

D108 CELL FATE DECISIONS: SENESCENCE, REPAIR, AND REGENERATION: Activation Of The Mtor Pathway Drives Lung Cell Senescence And Emphysema In Chronic Obstructive Pulmonary Disease (COPD)

[...]we developed transgenic mice exhibiting mTOR overactivity in lung ECs, alveolar epithelial cells (AEC), or SMCs. Methods and Results: Studies of lung specimens and derived cultured cells from patients with COPD and control smokers showed that cell senescence in COPD was linked to mTOR activatio...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Houssaini, A, Breau, M, Kebe, K, Abid, S, Marcos, E, Lipskaia, L, Rideau, D, Parpaleix, A, Huang, J, Amsellem, V, Maitre, B, Bizard, E, Vienney, N, Luka, C, Validyre, P, Boczkowski, J, Derumeaux, G, Bernard, D, Meiners, S, Adnot, S
Format: Artikel
Sprache:eng
Schlagworte:
Chronic obstructive pulmonary disease
Pulmonary arteries
Rodents
Senescence
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Zusammenfassung:[...]we developed transgenic mice exhibiting mTOR overactivity in lung ECs, alveolar epithelial cells (AEC), or SMCs. Methods and Results: Studies of lung specimens and derived cultured cells from patients with COPD and control smokers showed that cell senescence in COPD was linked to mTOR activation and that mTOR inhibition by low-dose rapamycin prevented cell senescence and inhibited the proinflammatory SASP.
ISSN:1073-449X
1535-4970