C14 INTERSTITIAL LUNG DISEASE: ADVANCES ACROSS THE FIELD: Clinical Associations Of Objectively Identified Interstitial Changes In Smokers

Rationale: Interstitial lung abnormalities (ILA) identified visually by computed tomography (CT) may represent early pulmonary fibrosis, and have been associated with reduced lung function and increased mortality, as well as a single nucleotide polymorphism in the promoter of the gene encoding mucin 5b (MUC5B). Multivariable analyses were adjusted for age, sex, race, body mass index, smoking status, pack years, clinical center and percent predicted forced expiratory volume in one second (FEV1%), except for the analysis of forced vital capacity (FVC%) where FEV1% was not included.