C19 MOLECULAR MECHANISMS OF DYSREGULATED INFLAMMATION, PROLIFERATION, AND REPAIR IN THORACIC ONCOLOGY: Dna Repair Protein Xpc Alters Pulmonary Cell Fate Following Cigarette Smoke Exposure And May Play A Role In Emphysema And Lung Cancer Development
Background: Although cigarette smoke (CS) exposure is the main risk factor for emphysema or lung cancer, a minority of smokers develop these diseases, implicating an important role for gene-environment interactions in pathogenesis. CS is a potent inducer of oxidative and complex DNA damage, which wh...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2017-01, Vol.195 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Sears, C R Zhou, H Fisher, A J Justice, M J Van Demark, M Saliba, J Sandusky, G E Petrache, I |
| description | Background: Although cigarette smoke (CS) exposure is the main risk factor for emphysema or lung cancer, a minority of smokers develop these diseases, implicating an important role for gene-environment interactions in pathogenesis. CS is a potent inducer of oxidative and complex DNA damage, which when insufficiently repaired could induce apoptosis or autophagy, both of which contribute to emphysema development and alterations of which are essential to lung cancer development. [...]the susceptibility for both emphysema and lung cancer following CS exposure may be increased by abnormal DNA repair, such as that influenced by xeroderma pigmentosum group C (XPC). |
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| fulltext | fulltext |
| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2017-01, Vol.195 |
| issn | 1073-449X 1535-4970 |
| language | eng |
| recordid | cdi_proquest_journals_1926719764 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Apoptosis Autophagy Deoxyribonucleic acid DNA DNA damage DNA repair Emphysema Lung cancer |
| title | C19 MOLECULAR MECHANISMS OF DYSREGULATED INFLAMMATION, PROLIFERATION, AND REPAIR IN THORACIC ONCOLOGY: Dna Repair Protein Xpc Alters Pulmonary Cell Fate Following Cigarette Smoke Exposure And May Play A Role In Emphysema And Lung Cancer Development |
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