C14 INTERSTITIAL LUNG DISEASE: ADVANCES ACROSS THE FIELD: The Muc5b Promoter Polymorphism Is Associated With Specific Interstitial Lung Abnormality Subtypes Across Populations

Corresponding author's email: rputman@partners.org Rationale: Although the MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population, it is not known if these findings replicate in diverse populations and if they are influenced by ILA subtype. When added to models of best fitting clinical characteristics, knowledge of MUC5B genotype improved risk prediction for having a possible or definite UIP pattern in white populations (c-statistic 0.70 to 0.76, P=0.001 for comparison, and c-statistic 0.71 to 0.75, P=0.0008 for comparison in the AGES-Reykjavik and in NHW participants from COPDGene, respectively).