An epigenome-wide association study of total serum IgE in Hispanic children

Background Total IgE is a therapeutic target in patients with allergic diseases. DNA methylation in white blood cells (WBCs) was associated with total IgE levels in an epigenome-wide association study of white subjects. Whether DNA methylation of eosinophils explains these findings is insufficiently...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2017-08, Vol.140 (2), p.571-577
Hauptverfasser:	Chen, Wei, PhD, Wang, Ting, PhD, Pino-Yanes, Maria, PhD, Forno, Erick, MD, MPH, Liang, Liming, PhD, Yan, Qi, PhD, Hu, Donglei, PhD, Weeks, Daniel E., PhD, Baccarelli, Andrea, MD, PhD, Acosta-Perez, Edna, PhD, Eng, Celeste, MS, Han, Yueh-Ying, PhD, Boutaoui, Nadia, PhD, Laprise, Catherine, PhD, Davies, Gwyneth A., MD, Hopkin, Julian M., MD, Moffatt, Miriam F., DPhil, Cookson, William O.C.M., MD, Canino, Glorisa, PhD, Burchard, Esteban G., MD, MPH, Celedón, Juan C., MD, DrPH, FAAAAI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adolescent Adult Allergic diseases Allergies Allergy and Immunology Asthma Asthma - blood Asthma - genetics Asthma - immunology Child Children Children & youth CpG Islands Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic Epigenetics Epigenome-wide association study Female Gene expression Genetics Genome, Human Genome-Wide Association Study Genomes Genomics Hispanic Hispanic Americans Hispanic or Latino - genetics Humans Immune response Immunoglobulin E Immunoglobulin E - blood Leukocytes (basophilic) Leukocytes (eosinophilic) Leukocytes (neutrophilic) Leukocytes - metabolism Lymphocytes Male Monocytes Peripheral blood Principal components analysis total IgE Young Adult
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