The influence of glucosamine and Ketoprofen combination in the form of cream-gel on connective tissue metabolism indicators of rats with experimental osteoarthritis

The article presents the results of experimental study of chondroprotective activity of glucosamine hydrochloride and ketoprofen combination in topical dosage form. The study was carried out on a model of systemic steroid osteoarthritis in rats. To evaluate the chondroprotective activity the following biochemical parameters like the content of sialic acids, glycoproteins, chondroitin sulphates, total and fractions glycosaminoglycans in blood serum and content of endogenous N-acetylglucosamine were used. Fastum gel 5%, glucosamine ?ream gel 5% were used as a comparison agents that were applied in a similar way with equivalent therapeutic dose. As a result of biochemical studies research combination was showing a positive effect on the experimental osteoarthritis in rats that proves its chondroprotective properties, and some data exceeding the level of activity of comparison drugs.