Design and development of Aceclofenac fast dissolving tablets by different techniques

Aceclofenac is [[[2-[(2, 6, Dichlorophenyl) amino] phenyl] acetyl] oxy] acetic acid. It is a novel nonsteroidal anti-inflammatory drug indicated for symptomatic treatment for pain and inflammation. In the present work fast dissolving tablets of Aceclofenac were prepared by direct compression, sublimation and effervescent methods. The prepared tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug-polymer interaction by drug content, water absorption ratio, wetting time, in vitro drug release, FTIR studies and DSC studies, short term stability studies.