Evaluation of immunomodulatory action of atorvastatin calcium in mice

Evaluation of immunomodulatory action of atorvastatin calcium in mice

Objectives 1. To evaluate immunomodulatory activity of atorvastatin calcium by using host resistance model against E. coli induced sepsis in mice 2. To elucidate probable mechanism of action of immunomodulatory activity of atorvastatin calcium & septilin syrup. Methods: Immunomodulatory activity...

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Veröffentlicht in:The pharma innovation 2017-02, Vol.6 (2, Part B), p.105
Hauptverfasser: Barde, Anita, Yadav, Shraddha, Worlikar, Pratibha, Tilak, Abhijeet, Kumar, Harsh, Gupta, Tanya
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Bone marrow
Rodents
Sepsis
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container_issue 2, Part B
container_start_page 105
container_title The pharma innovation
container_volume 6
creator Barde, Anita
Yadav, Shraddha
Worlikar, Pratibha
Tilak, Abhijeet
Kumar, Harsh
Gupta, Tanya
description Objectives 1. To evaluate immunomodulatory activity of atorvastatin calcium by using host resistance model against E. coli induced sepsis in mice 2. To elucidate probable mechanism of action of immunomodulatory activity of atorvastatin calcium & septilin syrup. Methods: Immunomodulatory activity of atorvastatin calcium was evaluated by using host resistance model against E.coli induced sepsis. The mechanism of action was studied in survived mice from sepsis, by studying histopathology of spleen, thymus along with evaluation of bone marrow. Results: The atorvastatin calcium have increased the survival in sepsis induced mice & also decreased apoptosis of T & B cells by stimulating cellularity in PALS, marginal zone & follicles of spleen as well as cortex, medulla of thymus. The test drugs also increased myeloid+lymphoid cells in bone marrow. All the results were statistically significant as compared with control & were comparable with septilin syrup group which was used as positive control. Conclusion: Pretreatment of atorvastatin calcium as well as Septilin syrup before induction of sepsis have shown prominent increase in the survival rate due to their immunostimulant activity.
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To evaluate immunomodulatory activity of atorvastatin calcium by using host resistance model against E. coli induced sepsis in mice 2. To elucidate probable mechanism of action of immunomodulatory activity of atorvastatin calcium &amp; septilin syrup. Methods: Immunomodulatory activity of atorvastatin calcium was evaluated by using host resistance model against E.coli induced sepsis. The mechanism of action was studied in survived mice from sepsis, by studying histopathology of spleen, thymus along with evaluation of bone marrow. Results: The atorvastatin calcium have increased the survival in sepsis induced mice &amp; also decreased apoptosis of T &amp; B cells by stimulating cellularity in PALS, marginal zone &amp; follicles of spleen as well as cortex, medulla of thymus. The test drugs also increased myeloid+lymphoid cells in bone marrow. All the results were statistically significant as compared with control &amp; were comparable with septilin syrup group which was used as positive control. Conclusion: Pretreatment of atorvastatin calcium as well as Septilin syrup before induction of sepsis have shown prominent increase in the survival rate due to their immunostimulant activity.</description><identifier>EISSN: 2277-7695</identifier><language>eng</language><publisher>New Delhi: The Pharma Innovation</publisher><subject>Bone marrow ; Rodents ; Sepsis</subject><ispartof>The pharma innovation, 2017-02, Vol.6 (2, Part B), p.105</ispartof><rights>Copyright The Pharma Innovation Feb 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Barde, Anita</creatorcontrib><creatorcontrib>Yadav, Shraddha</creatorcontrib><creatorcontrib>Worlikar, Pratibha</creatorcontrib><creatorcontrib>Tilak, Abhijeet</creatorcontrib><creatorcontrib>Kumar, Harsh</creatorcontrib><creatorcontrib>Gupta, Tanya</creatorcontrib><title>Evaluation of immunomodulatory action of atorvastatin calcium in mice</title><title>The pharma innovation</title><description>Objectives 1. 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To evaluate immunomodulatory activity of atorvastatin calcium by using host resistance model against E. coli induced sepsis in mice 2. To elucidate probable mechanism of action of immunomodulatory activity of atorvastatin calcium &amp; septilin syrup. Methods: Immunomodulatory activity of atorvastatin calcium was evaluated by using host resistance model against E.coli induced sepsis. The mechanism of action was studied in survived mice from sepsis, by studying histopathology of spleen, thymus along with evaluation of bone marrow. Results: The atorvastatin calcium have increased the survival in sepsis induced mice &amp; also decreased apoptosis of T &amp; B cells by stimulating cellularity in PALS, marginal zone &amp; follicles of spleen as well as cortex, medulla of thymus. The test drugs also increased myeloid+lymphoid cells in bone marrow. 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subjects Bone marrow
Rodents
Sepsis
title Evaluation of immunomodulatory action of atorvastatin calcium in mice
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