Multi-Reservoir Phospholipid Shell Encapsulating Protamine Nanocapsules for Co-Delivery of Letrozole and Celecoxib in Breast Cancer Therapy

Purpose In the current work, we propose a combined delivery nanoplatform for letrozole (LTZ) and celecoxib (CXB). Methods Multi-reservoir nanocarriers were developed by enveloping protamine nanocapsules (PRM-NCs) within drug-phospholipid complex bilayer. Results Encapsulation of NCs within phospholi...

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Veröffentlicht in:	Pharmaceutical research 2017-09, Vol.34 (9), p.1956-1969
Hauptverfasser:	Elzoghby, Ahmed O., Mostafa, Shaimaa K., Helmy, Maged W., ElDemellawy, Maha A., Sheweita, Salah A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Angiogenesis inhibitors Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Aromatase Ascites Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood proteins Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cancer therapies Care and treatment Caspase Celecoxib Celecoxib - administration & dosage Celecoxib - pharmacokinetics Celecoxib - pharmacology Celecoxib - therapeutic use Circulation Coatings Core-shell structure Cytotoxicity Drug Carriers - chemistry Drug Combinations Drug therapy Encapsulation Ethylenediaminetetraacetic acid Female Health aspects Humans Inhibition Intravenous administration Letrozole Mammary gland MCF-7 Cells Medical Law Mice Mice, Inbred BALB C Nanocapsules - chemistry Nitriles - administration & dosage Nitriles - pharmacokinetics Nitriles - pharmacology Nitriles - therapeutic use Pharmacology/Toxicology Pharmacy Phospholipids Phospholipids - chemistry Protamine sulfate Protamines - chemistry Proteins Rats Rats, Sprague-Dawley Research Paper Reservoirs Rodents Serum proteins Surface charge Triazoles - administration & dosage Triazoles - pharmacokinetics Triazoles - pharmacology Triazoles - therapeutic use Tumor necrosis factor Tumors Vascular endothelial growth factor
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