GATA3 interacts with and stabilizes HIF-1[alpha] to enhance cancer cell invasiveness

GATA binding protein 3 (GATA3) is indispensable in development of human organs. However, the role of GATA3 in cancers remains elusive. Hypoxia inducible factor (HIF)-1 plays an important role in pathogenesis of human cancers. Regulation of HIF-1[alpha] degradation is orchestrated through collaborati...

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