The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis
Summary Background To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non‐invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non‐UC colitis. Vol...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2017-05, Vol.45 (9), p.1244-1254 |
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| creator | Smolinska, A. Bodelier, A. G. L. Dallinga, J. W. Masclee, A. A. M. Jonkers, D. M. Schooten, F.‐J. Pierik, M. J. |
| description | Summary
Background
To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non‐invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non‐UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease.
Aim
To investigate whether VOCs are able to differentiate between active UC, UC in remission and non‐UC colitis.
Methods
UC patients participated in a 1‐year study. Clinical activity index, blood, faecal and breath samples were collected at each out‐patient visit. Patients with clear defined active faecal calprotectin >250 μg/g and inactive disease (Simple Clinical Colitis Activity Index |
| doi_str_mv | 10.1111/apt.14004 |
| format | Article |
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Background
To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non‐invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non‐UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease.
Aim
To investigate whether VOCs are able to differentiate between active UC, UC in remission and non‐UC colitis.
Methods
UC patients participated in a 1‐year study. Clinical activity index, blood, faecal and breath samples were collected at each out‐patient visit. Patients with clear defined active faecal calprotectin >250 μg/g and inactive disease (Simple Clinical Colitis Activity Index <3, C‐reactive protein <5 mg/L and faecal calprotectin <100 μg/g) were included for cross‐sectional analysis. Non‐UC colitis was confirmed by stool culture or radiological evaluation. Breath samples were analysed by gas chromatography time‐of‐flight mass spectrometry and kernel‐based method to identify discriminating VOCs.
Results
In total, 72 UC (132 breath samples; 62 active; 70 remission) and 22 non‐UC‐colitis patients (22 samples) were included. Eleven VOCs predicted active vs. inactive UC in an independent internal validation set with 92% sensitivity and 77% specificity (AUC 0.94). Non‐UC colitis patients could be clearly separated from active and inactive UC patients with principal component analysis.
Conclusions
Volatile organic compounds can accurately distinguish active disease from remission in UC and profiles in UC are clearly different from profiles in non‐UC colitis patients. VOCs have demonstrated potential as new non‐invasive biomarker to monitor inflammation in UC.
Linked ContentThis article is linked to Smolinska and van Schooten, and Williams and Orchard papers. To view these articles visit https://doi.org/10.1111/apt.14163 and https://doi.org/10.1111/apt.14135.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.14004</identifier><identifier>PMID: 28239876</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers - analysis ; Breath Tests ; C-reactive protein ; C-Reactive Protein - analysis ; Colitis - blood ; Colitis - diagnosis ; Colon ; Crohn's disease ; Cross-Sectional Studies ; Feces - chemistry ; Female ; Gas chromatography ; Gas Chromatography-Mass Spectrometry ; Humans ; Inflammatory bowel disease ; Leukocyte L1 Antigen Complex - analysis ; Male ; Mass spectrometry ; Mass spectroscopy ; Middle Aged ; Mucosa ; Organic compounds ; Outpatients ; Principal components analysis ; Remission ; Sensitivity and Specificity ; Ulcerative colitis ; VOCs ; Volatile organic compounds ; Volatile Organic Compounds - analysis</subject><ispartof>Alimentary pharmacology & therapeutics, 2017-05, Vol.45 (9), p.1244-1254</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3884-892128fd1a5867c58e9d261cea0be1b0c437f9946876a07c15e80a5666d351633</citedby><cites>FETCH-LOGICAL-c3884-892128fd1a5867c58e9d261cea0be1b0c437f9946876a07c15e80a5666d351633</cites><orcidid>0000-0002-2329-9995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.14004$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.14004$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28239876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smolinska, A.</creatorcontrib><creatorcontrib>Bodelier, A. G. L.</creatorcontrib><creatorcontrib>Dallinga, J. W.</creatorcontrib><creatorcontrib>Masclee, A. A. M.</creatorcontrib><creatorcontrib>Jonkers, D. M.</creatorcontrib><creatorcontrib>Schooten, F.‐J.</creatorcontrib><creatorcontrib>Pierik, M. J.</creatorcontrib><title>The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non‐invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non‐UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease.
Aim
To investigate whether VOCs are able to differentiate between active UC, UC in remission and non‐UC colitis.
Methods
UC patients participated in a 1‐year study. Clinical activity index, blood, faecal and breath samples were collected at each out‐patient visit. Patients with clear defined active faecal calprotectin >250 μg/g and inactive disease (Simple Clinical Colitis Activity Index <3, C‐reactive protein <5 mg/L and faecal calprotectin <100 μg/g) were included for cross‐sectional analysis. Non‐UC colitis was confirmed by stool culture or radiological evaluation. Breath samples were analysed by gas chromatography time‐of‐flight mass spectrometry and kernel‐based method to identify discriminating VOCs.
Results
In total, 72 UC (132 breath samples; 62 active; 70 remission) and 22 non‐UC‐colitis patients (22 samples) were included. Eleven VOCs predicted active vs. inactive UC in an independent internal validation set with 92% sensitivity and 77% specificity (AUC 0.94). Non‐UC colitis patients could be clearly separated from active and inactive UC patients with principal component analysis.
Conclusions
Volatile organic compounds can accurately distinguish active disease from remission in UC and profiles in UC are clearly different from profiles in non‐UC colitis patients. VOCs have demonstrated potential as new non‐invasive biomarker to monitor inflammation in UC.
Linked ContentThis article is linked to Smolinska and van Schooten, and Williams and Orchard papers. To view these articles visit https://doi.org/10.1111/apt.14163 and https://doi.org/10.1111/apt.14135.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - analysis</subject><subject>Breath Tests</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Colitis - blood</subject><subject>Colitis - diagnosis</subject><subject>Colon</subject><subject>Crohn's disease</subject><subject>Cross-Sectional Studies</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Leukocyte L1 Antigen Complex - analysis</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Organic compounds</subject><subject>Outpatients</subject><subject>Principal components analysis</subject><subject>Remission</subject><subject>Sensitivity and Specificity</subject><subject>Ulcerative colitis</subject><subject>VOCs</subject><subject>Volatile organic compounds</subject><subject>Volatile Organic Compounds - analysis</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwyAYgInRuDk9-AcMiScP3fhoKT0ui1-JiR7muWH0rWPpSgW6Zf9e9qE3uUDIw_OGB6FbSsY0ronqwpimhKRnaEi5yBJGuDhHQ8JEkTBJ-QBdeb8ihIicsEs0YJLxQuZiiPx8CbizAdpgVINtjTe2UcE0gK37Uq3RWNt1Z_u28ri2DofIVxBAB2PbPa_iaRPvjAflAZsWd_F99Hm8NWGJ-0aDUwdG28YE46_RRa0aDzenfYQ-nx7ns5fk7f35dTZ9SzSXMk1kwSiTdUVVJkWuMwlFxQTVoMgC6ILolOd1UaQifkSRXNMMJFGZEKLiGRWcj9D90ds5-92DD-XK9q6NI0taMJamnNAsUg9HSjvrvYO67JxZK7crKSn3ecuYtzzkjezdydgv1lD9kb89IzA5AttYcPe_qZx-zI_KHzLXhJI</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Smolinska, A.</creator><creator>Bodelier, A. G. L.</creator><creator>Dallinga, J. W.</creator><creator>Masclee, A. A. M.</creator><creator>Jonkers, D. M.</creator><creator>Schooten, F.‐J.</creator><creator>Pierik, M. J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><orcidid>https://orcid.org/0000-0002-2329-9995</orcidid></search><sort><creationdate>201705</creationdate><title>The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis</title><author>Smolinska, A. ; Bodelier, A. G. L. ; Dallinga, J. W. ; Masclee, A. A. M. ; Jonkers, D. M. ; Schooten, F.‐J. ; Pierik, M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3884-892128fd1a5867c58e9d261cea0be1b0c437f9946876a07c15e80a5666d351633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - analysis</topic><topic>Breath Tests</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Colitis - blood</topic><topic>Colitis - diagnosis</topic><topic>Colon</topic><topic>Crohn's disease</topic><topic>Cross-Sectional Studies</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Leukocyte L1 Antigen Complex - analysis</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Organic compounds</topic><topic>Outpatients</topic><topic>Principal components analysis</topic><topic>Remission</topic><topic>Sensitivity and Specificity</topic><topic>Ulcerative colitis</topic><topic>VOCs</topic><topic>Volatile organic compounds</topic><topic>Volatile Organic Compounds - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smolinska, A.</creatorcontrib><creatorcontrib>Bodelier, A. G. L.</creatorcontrib><creatorcontrib>Dallinga, J. W.</creatorcontrib><creatorcontrib>Masclee, A. A. M.</creatorcontrib><creatorcontrib>Jonkers, D. M.</creatorcontrib><creatorcontrib>Schooten, F.‐J.</creatorcontrib><creatorcontrib>Pierik, M. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smolinska, A.</au><au>Bodelier, A. G. L.</au><au>Dallinga, J. W.</au><au>Masclee, A. A. M.</au><au>Jonkers, D. M.</au><au>Schooten, F.‐J.</au><au>Pierik, M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2017-05</date><risdate>2017</risdate><volume>45</volume><issue>9</issue><spage>1244</spage><epage>1254</epage><pages>1244-1254</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non‐invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non‐UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease.
Aim
To investigate whether VOCs are able to differentiate between active UC, UC in remission and non‐UC colitis.
Methods
UC patients participated in a 1‐year study. Clinical activity index, blood, faecal and breath samples were collected at each out‐patient visit. Patients with clear defined active faecal calprotectin >250 μg/g and inactive disease (Simple Clinical Colitis Activity Index <3, C‐reactive protein <5 mg/L and faecal calprotectin <100 μg/g) were included for cross‐sectional analysis. Non‐UC colitis was confirmed by stool culture or radiological evaluation. Breath samples were analysed by gas chromatography time‐of‐flight mass spectrometry and kernel‐based method to identify discriminating VOCs.
Results
In total, 72 UC (132 breath samples; 62 active; 70 remission) and 22 non‐UC‐colitis patients (22 samples) were included. Eleven VOCs predicted active vs. inactive UC in an independent internal validation set with 92% sensitivity and 77% specificity (AUC 0.94). Non‐UC colitis patients could be clearly separated from active and inactive UC patients with principal component analysis.
Conclusions
Volatile organic compounds can accurately distinguish active disease from remission in UC and profiles in UC are clearly different from profiles in non‐UC colitis patients. VOCs have demonstrated potential as new non‐invasive biomarker to monitor inflammation in UC.
Linked ContentThis article is linked to Smolinska and van Schooten, and Williams and Orchard papers. To view these articles visit https://doi.org/10.1111/apt.14163 and https://doi.org/10.1111/apt.14135.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28239876</pmid><doi>10.1111/apt.14004</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2329-9995</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Biomarkers - analysis Breath Tests C-reactive protein C-Reactive Protein - analysis Colitis - blood Colitis - diagnosis Colon Crohn's disease Cross-Sectional Studies Feces - chemistry Female Gas chromatography Gas Chromatography-Mass Spectrometry Humans Inflammatory bowel disease Leukocyte L1 Antigen Complex - analysis Male Mass spectrometry Mass spectroscopy Middle Aged Mucosa Organic compounds Outpatients Principal components analysis Remission Sensitivity and Specificity Ulcerative colitis VOCs Volatile organic compounds Volatile Organic Compounds - analysis |
| title | The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis |
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