Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga

Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studyi...

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Veröffentlicht in:Fish physiology and biochemistry 2017-08, Vol.43 (4), p.1095-1104
Hauptverfasser: Sayed, Alaa El-Din H., Ismail, Rania F. K.
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description Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince ( Cydonia oblonga ). To fulfill this aim, catfish Clarias gariepinus were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17ß-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level. Moreover, 4-NP exposure was accompanied by histological impairments in testes. Existence of 4-NP was associated with oxidative damage as evidenced by the significant increase ( p <  0.05) of the enzymes, superoxidase dismutase (SOD), catalase (CAT), acetylcholinesterase (AchE), glutathione s-transferase, total antioxidant capacity (TAC), and malondialdehyde (MDA). Adding quince was effective to neutralize hormonal levels and to repair the testicular histological alterations. In response to quince remedy, the enzymes AchE and MDA reduced significantly ( p <  0.05), while limited or no response was detected for other tested enzymes. Our results concluded that quince can antagonize 4-NP toxicity in catfish, confirming that quince leaf extract displayed antioxidant activities against the toxicity of hazardous chemicals.
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ispartof Fish physiology and biochemistry, 2017-08, Vol.43 (4), p.1095-1104
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subjects 17β-Estradiol
Acetylcholinesterase
Animal Anatomy
Animal Biochemistry
Animal Physiology
Animal reproductive organs
Animals
Antioxidants
Antioxidants - metabolism
Biomedical and Life Sciences
Catalase
Catfish
Catfishes
Clarias gariepinus
Cortisol
Cydonia oblonga
Damage
Endocrine disruptors
Endocrine Disruptors - toxicity
Enzymes
Enzymes - metabolism
Exposure
Fish
Follicle-stimulating hormone
Freshwater & Marine Ecology
Freshwater fishes
Glutathione
Glutathione transferase
Histology
Hormones
Leaves
Life Sciences
Luteinizing hormone
Male
Males
Malondialdehyde
Morphology
Nonylphenol
Oxidative stress
Oxidative Stress - drug effects
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rosaceae - chemistry
Sex hormones
Testes
Testicular Diseases - chemically induced
Testicular Diseases - veterinary
Testis - drug effects
Testosterone
Thyroid
Thyroid gland
Thyroid-stimulating hormone
Thyroxine
Toxicity
Triiodothyronine
Xenoestrogens
Zoology
title Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga
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