Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga
Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studyi...
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description | Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (
Cydonia oblonga
). To fulfill this aim, catfish
Clarias gariepinus
were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17ß-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level. Moreover, 4-NP exposure was accompanied by histological impairments in testes. Existence of 4-NP was associated with oxidative damage as evidenced by the significant increase (
p <
0.05) of the enzymes, superoxidase dismutase (SOD), catalase (CAT), acetylcholinesterase (AchE), glutathione s-transferase, total antioxidant capacity (TAC), and malondialdehyde (MDA). Adding quince was effective to neutralize hormonal levels and to repair the testicular histological alterations. In response to quince remedy, the enzymes AchE and MDA reduced significantly (
p <
0.05), while limited or no response was detected for other tested enzymes. Our results concluded that quince can antagonize 4-NP toxicity in catfish, confirming that quince leaf extract displayed antioxidant activities against the toxicity of hazardous chemicals. |
doi_str_mv | 10.1007/s10695-017-0355-2 |
format | Article |
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Cydonia oblonga
). To fulfill this aim, catfish
Clarias gariepinus
were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17ß-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level. Moreover, 4-NP exposure was accompanied by histological impairments in testes. Existence of 4-NP was associated with oxidative damage as evidenced by the significant increase (
p <
0.05) of the enzymes, superoxidase dismutase (SOD), catalase (CAT), acetylcholinesterase (AchE), glutathione s-transferase, total antioxidant capacity (TAC), and malondialdehyde (MDA). Adding quince was effective to neutralize hormonal levels and to repair the testicular histological alterations. In response to quince remedy, the enzymes AchE and MDA reduced significantly (
p <
0.05), while limited or no response was detected for other tested enzymes. Our results concluded that quince can antagonize 4-NP toxicity in catfish, confirming that quince leaf extract displayed antioxidant activities against the toxicity of hazardous chemicals.</description><identifier>ISSN: 0920-1742</identifier><identifier>EISSN: 1573-5168</identifier><identifier>DOI: 10.1007/s10695-017-0355-2</identifier><identifier>PMID: 28285354</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>17β-Estradiol ; Acetylcholinesterase ; Animal Anatomy ; Animal Biochemistry ; Animal Physiology ; Animal reproductive organs ; Animals ; Antioxidants ; Antioxidants - metabolism ; Biomedical and Life Sciences ; Catalase ; Catfish ; Catfishes ; Clarias gariepinus ; Cortisol ; Cydonia oblonga ; Damage ; Endocrine disruptors ; Endocrine Disruptors - toxicity ; Enzymes ; Enzymes - metabolism ; Exposure ; Fish ; Follicle-stimulating hormone ; Freshwater & Marine Ecology ; Freshwater fishes ; Glutathione ; Glutathione transferase ; Histology ; Hormones ; Leaves ; Life Sciences ; Luteinizing hormone ; Male ; Males ; Malondialdehyde ; Morphology ; Nonylphenol ; Oxidative stress ; Oxidative Stress - drug effects ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Rosaceae - chemistry ; Sex hormones ; Testes ; Testicular Diseases - chemically induced ; Testicular Diseases - veterinary ; Testis - drug effects ; Testosterone ; Thyroid ; Thyroid gland ; Thyroid-stimulating hormone ; Thyroxine ; Toxicity ; Triiodothyronine ; Xenoestrogens ; Zoology</subject><ispartof>Fish physiology and biochemistry, 2017-08, Vol.43 (4), p.1095-1104</ispartof><rights>Springer Science+Business Media Dordrecht 2017</rights><rights>Fish Physiology and Biochemistry is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-71094d40f359e76b1a694fa0d408d4018747a19c95f5585779bb996ab0e8d6b33</citedby><cites>FETCH-LOGICAL-c438t-71094d40f359e76b1a694fa0d408d4018747a19c95f5585779bb996ab0e8d6b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10695-017-0355-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10695-017-0355-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28285354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sayed, Alaa El-Din H.</creatorcontrib><creatorcontrib>Ismail, Rania F. K.</creatorcontrib><title>Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga</title><title>Fish physiology and biochemistry</title><addtitle>Fish Physiol Biochem</addtitle><addtitle>Fish Physiol Biochem</addtitle><description>Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (
Cydonia oblonga
). To fulfill this aim, catfish
Clarias gariepinus
were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17ß-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level. Moreover, 4-NP exposure was accompanied by histological impairments in testes. Existence of 4-NP was associated with oxidative damage as evidenced by the significant increase (
p <
0.05) of the enzymes, superoxidase dismutase (SOD), catalase (CAT), acetylcholinesterase (AchE), glutathione s-transferase, total antioxidant capacity (TAC), and malondialdehyde (MDA). Adding quince was effective to neutralize hormonal levels and to repair the testicular histological alterations. In response to quince remedy, the enzymes AchE and MDA reduced significantly (
p <
0.05), while limited or no response was detected for other tested enzymes. Our results concluded that quince can antagonize 4-NP toxicity in catfish, confirming that quince leaf extract displayed antioxidant activities against the toxicity of hazardous chemicals.</description><subject>17β-Estradiol</subject><subject>Acetylcholinesterase</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animal Physiology</subject><subject>Animal reproductive organs</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Catalase</subject><subject>Catfish</subject><subject>Catfishes</subject><subject>Clarias gariepinus</subject><subject>Cortisol</subject><subject>Cydonia oblonga</subject><subject>Damage</subject><subject>Endocrine disruptors</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Enzymes</subject><subject>Enzymes - metabolism</subject><subject>Exposure</subject><subject>Fish</subject><subject>Follicle-stimulating hormone</subject><subject>Freshwater & Marine Ecology</subject><subject>Freshwater fishes</subject><subject>Glutathione</subject><subject>Glutathione transferase</subject><subject>Histology</subject><subject>Hormones</subject><subject>Leaves</subject><subject>Life Sciences</subject><subject>Luteinizing hormone</subject><subject>Male</subject><subject>Males</subject><subject>Malondialdehyde</subject><subject>Morphology</subject><subject>Nonylphenol</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rosaceae - chemistry</subject><subject>Sex hormones</subject><subject>Testes</subject><subject>Testicular Diseases - chemically induced</subject><subject>Testicular Diseases - veterinary</subject><subject>Testis - drug effects</subject><subject>Testosterone</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>Toxicity</subject><subject>Triiodothyronine</subject><subject>Xenoestrogens</subject><subject>Zoology</subject><issn>0920-1742</issn><issn>1573-5168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcFO3DAQhq2qqCzQB-ilstQrpuMktmNu1YoCElIvcLaceLIYZe3UTir2PXhgTBeqXjiMRpr55h97fkK-cDjjAOp75iC1YMAVg1oIVn0gKy5UzQSX7UeyAl0B46qpDslRzg8AoJXkn8hh1VatqEWzIk8XwcU--YDU-ZyWafYxnNL46J2d_R-keU6Y8ym1wdEZ8-z7ZbSJOru1G6Q-uKVHR7sdbViIYTdO9xjiWBp0XThvM92UhJMPSz6n8z3SKcUZ-7_iKY5I40DXOxeDtzR2Ywwbe0IOBjtm_Pyaj8ndz4vb9RW7-XV5vf5xw_qmbmemOOjGNTDUQqOSHbdSN4OFUmpL8FY1ynLdazEI0QqldNdpLW0H2DrZ1fUx-bbXLU_6vZTPmYe4pFBWGl5OJ6FWUhSK76k-xZwTDmZKfmvTznAwLz6YvQ-m-GBefDBVmfn6qrx0W3T_Jt4OX4BqD-TSChtM_61-V_UZgwaUpA</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Sayed, Alaa El-Din H.</creator><creator>Ismail, Rania F. 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K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-71094d40f359e76b1a694fa0d408d4018747a19c95f5585779bb996ab0e8d6b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>17β-Estradiol</topic><topic>Acetylcholinesterase</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animal Physiology</topic><topic>Animal reproductive organs</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Catalase</topic><topic>Catfish</topic><topic>Catfishes</topic><topic>Clarias gariepinus</topic><topic>Cortisol</topic><topic>Cydonia oblonga</topic><topic>Damage</topic><topic>Endocrine disruptors</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Enzymes</topic><topic>Enzymes - metabolism</topic><topic>Exposure</topic><topic>Fish</topic><topic>Follicle-stimulating hormone</topic><topic>Freshwater & Marine Ecology</topic><topic>Freshwater fishes</topic><topic>Glutathione</topic><topic>Glutathione transferase</topic><topic>Histology</topic><topic>Hormones</topic><topic>Leaves</topic><topic>Life Sciences</topic><topic>Luteinizing hormone</topic><topic>Male</topic><topic>Males</topic><topic>Malondialdehyde</topic><topic>Morphology</topic><topic>Nonylphenol</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Rosaceae - chemistry</topic><topic>Sex hormones</topic><topic>Testes</topic><topic>Testicular Diseases - chemically induced</topic><topic>Testicular Diseases - veterinary</topic><topic>Testis - drug effects</topic><topic>Testosterone</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><topic>Toxicity</topic><topic>Triiodothyronine</topic><topic>Xenoestrogens</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sayed, Alaa El-Din H.</creatorcontrib><creatorcontrib>Ismail, Rania F. 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K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga</atitle><jtitle>Fish physiology and biochemistry</jtitle><stitle>Fish Physiol Biochem</stitle><addtitle>Fish Physiol Biochem</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>43</volume><issue>4</issue><spage>1095</spage><epage>1104</epage><pages>1095-1104</pages><issn>0920-1742</issn><eissn>1573-5168</eissn><abstract>Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (
Cydonia oblonga
). To fulfill this aim, catfish
Clarias gariepinus
were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17ß-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level. Moreover, 4-NP exposure was accompanied by histological impairments in testes. Existence of 4-NP was associated with oxidative damage as evidenced by the significant increase (
p <
0.05) of the enzymes, superoxidase dismutase (SOD), catalase (CAT), acetylcholinesterase (AchE), glutathione s-transferase, total antioxidant capacity (TAC), and malondialdehyde (MDA). Adding quince was effective to neutralize hormonal levels and to repair the testicular histological alterations. In response to quince remedy, the enzymes AchE and MDA reduced significantly (
p <
0.05), while limited or no response was detected for other tested enzymes. Our results concluded that quince can antagonize 4-NP toxicity in catfish, confirming that quince leaf extract displayed antioxidant activities against the toxicity of hazardous chemicals.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>28285354</pmid><doi>10.1007/s10695-017-0355-2</doi><tpages>10</tpages></addata></record> |
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subjects | 17β-Estradiol Acetylcholinesterase Animal Anatomy Animal Biochemistry Animal Physiology Animal reproductive organs Animals Antioxidants Antioxidants - metabolism Biomedical and Life Sciences Catalase Catfish Catfishes Clarias gariepinus Cortisol Cydonia oblonga Damage Endocrine disruptors Endocrine Disruptors - toxicity Enzymes Enzymes - metabolism Exposure Fish Follicle-stimulating hormone Freshwater & Marine Ecology Freshwater fishes Glutathione Glutathione transferase Histology Hormones Leaves Life Sciences Luteinizing hormone Male Males Malondialdehyde Morphology Nonylphenol Oxidative stress Oxidative Stress - drug effects Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Rosaceae - chemistry Sex hormones Testes Testicular Diseases - chemically induced Testicular Diseases - veterinary Testis - drug effects Testosterone Thyroid Thyroid gland Thyroid-stimulating hormone Thyroxine Toxicity Triiodothyronine Xenoestrogens Zoology |
title | Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga |
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