Inactivation of Norovirus by Lemongrass Essential Oil Using a Norovirus Surrogate System
This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a si...
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| Veröffentlicht in: | Journal of food protection 2017-08, Vol.80 (8), p.1293-1302 |
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| creator | Kim, Ye Won You, Hyun Ju Lee, Soyoung Kim, Bomi Kim, Do Kyung Choi, Joo-Bong Kim, Ji-Ah Lee, Hee Jung Joo, In Sun Lee, Jeong Su Kang, Dong Hyun Lee, Giljae Ko, Gwang Pyo Lee, Sung-Joon |
| description | This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay. It was revealed that citral, a single compound in LGEO, showed dramatic reduction in MNV-1 infectivity (-73.09% when using a treatment of 0.02%, v/v). The inhibitory activity of LGEO on viral replication was further investigated in HG23 cells that harbored a human norovirus replicon. LGEO treatment significantly reduced viral replication in HG23 cells, which suggests that LGEO may have dual inhibitory activities that inactivate viral coat proteins required for viral infection and suppress norovirus genome replication in host cells. In animal experiments, oral administration of murine norovirus preincubated with LGEO significantly suppressed virus infectivity in vivo. Collectively, these results suggest that LGEO, in particular the LGEO component citral, inactivates the norovirus and its subsequent replication in host cells. Thus, LGEO shows promise as a method of inhibiting norovirus within the food industry. |
| doi_str_mv | 10.4315/0362-028X.JFP-16-162 |
| format | Article |
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Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay. It was revealed that citral, a single compound in LGEO, showed dramatic reduction in MNV-1 infectivity (-73.09% when using a treatment of 0.02%, v/v). The inhibitory activity of LGEO on viral replication was further investigated in HG23 cells that harbored a human norovirus replicon. LGEO treatment significantly reduced viral replication in HG23 cells, which suggests that LGEO may have dual inhibitory activities that inactivate viral coat proteins required for viral infection and suppress norovirus genome replication in host cells. In animal experiments, oral administration of murine norovirus preincubated with LGEO significantly suppressed virus infectivity in vivo. Collectively, these results suggest that LGEO, in particular the LGEO component citral, inactivates the norovirus and its subsequent replication in host cells. Thus, LGEO shows promise as a method of inhibiting norovirus within the food industry.</description><identifier>ISSN: 0362-028X</identifier><identifier>EISSN: 1944-9097</identifier><identifier>DOI: 10.4315/0362-028X.JFP-16-162</identifier><identifier>PMID: 28699786</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Animal research ; Animals ; Assaying ; Caliciviridae Infections ; Cell culture ; Citral ; Cymbopogon - chemistry ; Deactivation ; Environmental protection ; Essential oils ; Food ; Food industry ; Food processing industry ; Food safety ; Genomes ; Humans ; Illnesses ; Inactivation ; Infections ; Infectivity ; Investigations ; Mice ; Norovirus - drug effects ; Norovirus - growth & development ; Oils & fats ; Oils, Volatile - pharmacology ; Oral administration ; Pathogens ; Polymerase chain reaction ; Polyphenols ; Proteins ; Real time ; Reduction ; Replication ; Viral infections ; Virus Inactivation ; Viruses</subject><ispartof>Journal of food protection, 2017-08, Vol.80 (8), p.1293-1302</ispartof><rights>Copyright Allen Press Publishing Services Aug 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-353e254022ccf31205375f799e1268b5abba83af4c68b56af062f2b186dc72df3</citedby><cites>FETCH-LOGICAL-c381t-353e254022ccf31205375f799e1268b5abba83af4c68b56af062f2b186dc72df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1920600289?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28699786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ye Won</creatorcontrib><creatorcontrib>You, Hyun Ju</creatorcontrib><creatorcontrib>Lee, Soyoung</creatorcontrib><creatorcontrib>Kim, Bomi</creatorcontrib><creatorcontrib>Kim, Do Kyung</creatorcontrib><creatorcontrib>Choi, Joo-Bong</creatorcontrib><creatorcontrib>Kim, Ji-Ah</creatorcontrib><creatorcontrib>Lee, Hee Jung</creatorcontrib><creatorcontrib>Joo, In Sun</creatorcontrib><creatorcontrib>Lee, Jeong Su</creatorcontrib><creatorcontrib>Kang, Dong Hyun</creatorcontrib><creatorcontrib>Lee, Giljae</creatorcontrib><creatorcontrib>Ko, Gwang Pyo</creatorcontrib><creatorcontrib>Lee, Sung-Joon</creatorcontrib><title>Inactivation of Norovirus by Lemongrass Essential Oil Using a Norovirus Surrogate System</title><title>Journal of food protection</title><addtitle>J Food Prot</addtitle><description>This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay. It was revealed that citral, a single compound in LGEO, showed dramatic reduction in MNV-1 infectivity (-73.09% when using a treatment of 0.02%, v/v). The inhibitory activity of LGEO on viral replication was further investigated in HG23 cells that harbored a human norovirus replicon. LGEO treatment significantly reduced viral replication in HG23 cells, which suggests that LGEO may have dual inhibitory activities that inactivate viral coat proteins required for viral infection and suppress norovirus genome replication in host cells. In animal experiments, oral administration of murine norovirus preincubated with LGEO significantly suppressed virus infectivity in vivo. Collectively, these results suggest that LGEO, in particular the LGEO component citral, inactivates the norovirus and its subsequent replication in host cells. Thus, LGEO shows promise as a method of inhibiting norovirus within the food industry.</description><subject>Animal research</subject><subject>Animals</subject><subject>Assaying</subject><subject>Caliciviridae Infections</subject><subject>Cell culture</subject><subject>Citral</subject><subject>Cymbopogon - chemistry</subject><subject>Deactivation</subject><subject>Environmental protection</subject><subject>Essential oils</subject><subject>Food</subject><subject>Food industry</subject><subject>Food processing industry</subject><subject>Food safety</subject><subject>Genomes</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Inactivation</subject><subject>Infections</subject><subject>Infectivity</subject><subject>Investigations</subject><subject>Mice</subject><subject>Norovirus - drug effects</subject><subject>Norovirus - growth & development</subject><subject>Oils & fats</subject><subject>Oils, Volatile - pharmacology</subject><subject>Oral administration</subject><subject>Pathogens</subject><subject>Polymerase chain reaction</subject><subject>Polyphenols</subject><subject>Proteins</subject><subject>Real time</subject><subject>Reduction</subject><subject>Replication</subject><subject>Viral infections</subject><subject>Virus Inactivation</subject><subject>Viruses</subject><issn>0362-028X</issn><issn>1944-9097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpNkFFrwjAUhcPYmM7tH4wR2HNdctOmyeMQ3RwyB07wLaQ1kYptXNIK_vu16GRw4HLhnHO5H0KPlAxjRpMXwjhEBMRq-DH5iihvBVeoT2UcR5LI9Br1L5YeugthSwgBCfwW9UBwKVPB-2g1rXReFwddF67CzuJP592h8E3A2RHPTOmqjdch4HEIpqoLvcPzYoeXoag2WP9zLxrv3UbXBi-OoTblPbqxehfMw3kO0HIy_h69R7P523T0OotyJmgdsYQZSGICkOeWUSAJSxObSmkocJElOsu0YNrGebdxbQkHCxkVfJ2nsLZsgJ5PvXvvfhoTarV1ja_ak4pKILz9WcjWFZ9cuXcheGPV3hel9kdFiepwqo6V6lipFqeivBW0sadzeZOVZn0J_fFjv8Y6cTo</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Kim, Ye Won</creator><creator>You, Hyun Ju</creator><creator>Lee, 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of Norovirus by Lemongrass Essential Oil Using a Norovirus Surrogate System</title><author>Kim, Ye Won ; You, Hyun Ju ; Lee, Soyoung ; Kim, Bomi ; Kim, Do Kyung ; Choi, Joo-Bong ; Kim, Ji-Ah ; Lee, Hee Jung ; Joo, In Sun ; Lee, Jeong Su ; Kang, Dong Hyun ; Lee, Giljae ; Ko, Gwang Pyo ; Lee, Sung-Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-353e254022ccf31205375f799e1268b5abba83af4c68b56af062f2b186dc72df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal research</topic><topic>Animals</topic><topic>Assaying</topic><topic>Caliciviridae Infections</topic><topic>Cell culture</topic><topic>Citral</topic><topic>Cymbopogon - chemistry</topic><topic>Deactivation</topic><topic>Environmental protection</topic><topic>Essential oils</topic><topic>Food</topic><topic>Food industry</topic><topic>Food processing industry</topic><topic>Food safety</topic><topic>Genomes</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Inactivation</topic><topic>Infections</topic><topic>Infectivity</topic><topic>Investigations</topic><topic>Mice</topic><topic>Norovirus - drug effects</topic><topic>Norovirus - growth & development</topic><topic>Oils & fats</topic><topic>Oils, Volatile - pharmacology</topic><topic>Oral administration</topic><topic>Pathogens</topic><topic>Polymerase chain reaction</topic><topic>Polyphenols</topic><topic>Proteins</topic><topic>Real time</topic><topic>Reduction</topic><topic>Replication</topic><topic>Viral infections</topic><topic>Virus Inactivation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ye Won</creatorcontrib><creatorcontrib>You, Hyun Ju</creatorcontrib><creatorcontrib>Lee, Soyoung</creatorcontrib><creatorcontrib>Kim, Bomi</creatorcontrib><creatorcontrib>Kim, Do Kyung</creatorcontrib><creatorcontrib>Choi, 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food protection</jtitle><addtitle>J Food Prot</addtitle><date>2017-08</date><risdate>2017</risdate><volume>80</volume><issue>8</issue><spage>1293</spage><epage>1302</epage><pages>1293-1302</pages><issn>0362-028X</issn><eissn>1944-9097</eissn><abstract>This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay. It was revealed that citral, a single compound in LGEO, showed dramatic reduction in MNV-1 infectivity (-73.09% when using a treatment of 0.02%, v/v). The inhibitory activity of LGEO on viral replication was further investigated in HG23 cells that harbored a human norovirus replicon. LGEO treatment significantly reduced viral replication in HG23 cells, which suggests that LGEO may have dual inhibitory activities that inactivate viral coat proteins required for viral infection and suppress norovirus genome replication in host cells. In animal experiments, oral administration of murine norovirus preincubated with LGEO significantly suppressed virus infectivity in vivo. Collectively, these results suggest that LGEO, in particular the LGEO component citral, inactivates the norovirus and its subsequent replication in host cells. Thus, LGEO shows promise as a method of inhibiting norovirus within the food industry.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>28699786</pmid><doi>10.4315/0362-028X.JFP-16-162</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal research Animals Assaying Caliciviridae Infections Cell culture Citral Cymbopogon - chemistry Deactivation Environmental protection Essential oils Food Food industry Food processing industry Food safety Genomes Humans Illnesses Inactivation Infections Infectivity Investigations Mice Norovirus - drug effects Norovirus - growth & development Oils & fats Oils, Volatile - pharmacology Oral administration Pathogens Polymerase chain reaction Polyphenols Proteins Real time Reduction Replication Viral infections Virus Inactivation Viruses |
| title | Inactivation of Norovirus by Lemongrass Essential Oil Using a Norovirus Surrogate System |
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