BKV‐specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA‐haploidentical haematopoietic cell transplantation
Background Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA‐haploidentical transplantation. Adoptive immunotransfer of virus‐specific T cells from the donor is a promising therapeutic...
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| Veröffentlicht in: | European journal of haematology 2017-06, Vol.98 (6), p.632-634 |
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| container_title | European journal of haematology |
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| creator | Pello, Oscar M. Innes, Andrew J. Bradshaw, Anne Finn, Sally‐Anne Uddin, Shab Bray, Emma Olavarria, Eduardo Apperley, Jane F. Pavlů, Jiří |
| description | Background
Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA‐haploidentical transplantation. Adoptive immunotransfer of virus‐specific T cells from the donor is a promising therapeutic approach, although production of these cells is challenging, particularly when dealing with low‐frequency T cells such as BKV‐specific T cells.
Case report
Here, we present a patient who, following haploidentical HCT, developed severe BKV haemorrhagic cystitis, resistant to standard therapy. He responded well to adoptive transfer of donor cells enriched in BKV‐specific T cells using the new second‐generation CliniMACS Prodigy and the Cytokine Capture System from Miltenyi Biotec. Treatment led to full resolution of both the symptoms and viraemia without unwanted complications.
Conclusion
Our observations suggest that use of products enriched with BKV‐specific T cells generated using this system is safe and efficient in HLA‐haploidentical HCT where BKV cystitis can be a serious complication. |
| doi_str_mv | 10.1111/ejh.12848 |
| format | Article |
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Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA‐haploidentical transplantation. Adoptive immunotransfer of virus‐specific T cells from the donor is a promising therapeutic approach, although production of these cells is challenging, particularly when dealing with low‐frequency T cells such as BKV‐specific T cells.
Case report
Here, we present a patient who, following haploidentical HCT, developed severe BKV haemorrhagic cystitis, resistant to standard therapy. He responded well to adoptive transfer of donor cells enriched in BKV‐specific T cells using the new second‐generation CliniMACS Prodigy and the Cytokine Capture System from Miltenyi Biotec. Treatment led to full resolution of both the symptoms and viraemia without unwanted complications.
Conclusion
Our observations suggest that use of products enriched with BKV‐specific T cells generated using this system is safe and efficient in HLA‐haploidentical HCT where BKV cystitis can be a serious complication.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/ejh.12848</identifier><identifier>PMID: 28083990</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adoptive transfer ; Adult ; BK virus ; BK Virus - pathogenicity ; BK Virus - physiology ; case report ; CliniMACS Prodigy ; Cystitis ; Cystitis - etiology ; Cystitis - immunology ; Cystitis - pathology ; Cystitis - therapy ; donor‐specific T cells ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hemorrhage - etiology ; Hemorrhage - immunology ; Hemorrhage - pathology ; Hemorrhage - therapy ; Histocompatibility antigen HLA ; Histocompatibility Testing ; HLA transplantation ; Humans ; Immunotherapy, Adoptive ; Leukemia, Myeloid, Acute - immunology ; Leukemia, Myeloid, Acute - pathology ; Leukemia, Myeloid, Acute - therapy ; Lymphocytes ; Lymphocytes T ; Male ; Polyomavirus Infections - etiology ; Polyomavirus Infections - immunology ; Polyomavirus Infections - pathology ; Polyomavirus Infections - therapy ; T-Lymphocytes - transplantation ; Transplantation ; Transplantation, Isogeneic ; Treatment Outcome ; Tumor Virus Infections - etiology ; Tumor Virus Infections - immunology ; Tumor Virus Infections - pathology ; Tumor Virus Infections - therapy ; Viremia</subject><ispartof>European journal of haematology, 2017-06, Vol.98 (6), p.632-634</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3558-3fe9d6d166c13edd6c48a4eecb3dbdd11bf92a49395ba953ac31c66a7eb085dc3</citedby><cites>FETCH-LOGICAL-c3558-3fe9d6d166c13edd6c48a4eecb3dbdd11bf92a49395ba953ac31c66a7eb085dc3</cites><orcidid>0000-0002-6519-2598</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejh.12848$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejh.12848$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28083990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pello, Oscar M.</creatorcontrib><creatorcontrib>Innes, Andrew J.</creatorcontrib><creatorcontrib>Bradshaw, Anne</creatorcontrib><creatorcontrib>Finn, Sally‐Anne</creatorcontrib><creatorcontrib>Uddin, Shab</creatorcontrib><creatorcontrib>Bray, Emma</creatorcontrib><creatorcontrib>Olavarria, Eduardo</creatorcontrib><creatorcontrib>Apperley, Jane F.</creatorcontrib><creatorcontrib>Pavlů, Jiří</creatorcontrib><title>BKV‐specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA‐haploidentical haematopoietic cell transplantation</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>Background
Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA‐haploidentical transplantation. Adoptive immunotransfer of virus‐specific T cells from the donor is a promising therapeutic approach, although production of these cells is challenging, particularly when dealing with low‐frequency T cells such as BKV‐specific T cells.
Case report
Here, we present a patient who, following haploidentical HCT, developed severe BKV haemorrhagic cystitis, resistant to standard therapy. He responded well to adoptive transfer of donor cells enriched in BKV‐specific T cells using the new second‐generation CliniMACS Prodigy and the Cytokine Capture System from Miltenyi Biotec. Treatment led to full resolution of both the symptoms and viraemia without unwanted complications.
Conclusion
Our observations suggest that use of products enriched with BKV‐specific T cells generated using this system is safe and efficient in HLA‐haploidentical HCT where BKV cystitis can be a serious complication.</description><subject>Adoptive transfer</subject><subject>Adult</subject><subject>BK virus</subject><subject>BK Virus - pathogenicity</subject><subject>BK Virus - physiology</subject><subject>case report</subject><subject>CliniMACS Prodigy</subject><subject>Cystitis</subject><subject>Cystitis - etiology</subject><subject>Cystitis - immunology</subject><subject>Cystitis - pathology</subject><subject>Cystitis - therapy</subject><subject>donor‐specific T cells</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hemorrhage - etiology</subject><subject>Hemorrhage - immunology</subject><subject>Hemorrhage - pathology</subject><subject>Hemorrhage - therapy</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility Testing</subject><subject>HLA transplantation</subject><subject>Humans</subject><subject>Immunotherapy, Adoptive</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Polyomavirus Infections - etiology</subject><subject>Polyomavirus Infections - immunology</subject><subject>Polyomavirus Infections - pathology</subject><subject>Polyomavirus Infections - therapy</subject><subject>T-Lymphocytes - transplantation</subject><subject>Transplantation</subject><subject>Transplantation, Isogeneic</subject><subject>Treatment Outcome</subject><subject>Tumor Virus Infections - etiology</subject><subject>Tumor Virus Infections - immunology</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumor Virus Infections - therapy</subject><subject>Viremia</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLFu2zAURYkgQeI6HfoDAYFMGeSQoiSLo2s4dRsDXZKuwhP5VNGQRYWkE3jLJ6S_2C8pY7vdyoFczj0XvIR84mzC47nFdTvhaZmVJ2TEC8YSVjB5SkZMsjTJsoxfkA_erxljqeTTc3KRlqwUUrIR-fX5_sfv1zc_oDKNUfSBKuw6T01PQ4s0OISwwT5Q21CPz-iQOmwcqGDdjraAG-tcCz9jVO18MMF4Ck1AR5erWRS3MHTW6GgwCrp9AIIdrMHwHoldsQN6P3TQBwjG9pfkrIHO48fjOyaPd4uH-TJZff_ydT5bJUrkeZmIBqUuNC8KxQVqXaishAxR1ULXWnNeNzKFTAqZ1yBzAUpwVRQwxZqVuVZiTK4P3sHZpy36UK3t1vWxsuIyZdk03jxSNwdKOet9_Ho1OLMBt6s4q97Hr-L41X78yF4djdt6g_of-XftCNwegBfT4e7_pmrxbXlQ_gGXx5QL</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Pello, Oscar M.</creator><creator>Innes, Andrew J.</creator><creator>Bradshaw, Anne</creator><creator>Finn, Sally‐Anne</creator><creator>Uddin, Shab</creator><creator>Bray, Emma</creator><creator>Olavarria, Eduardo</creator><creator>Apperley, Jane F.</creator><creator>Pavlů, Jiří</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-6519-2598</orcidid></search><sort><creationdate>201706</creationdate><title>BKV‐specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA‐haploidentical haematopoietic cell transplantation</title><author>Pello, Oscar M. ; Innes, Andrew J. ; Bradshaw, Anne ; Finn, Sally‐Anne ; Uddin, Shab ; Bray, Emma ; Olavarria, Eduardo ; Apperley, Jane F. ; Pavlů, Jiří</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3558-3fe9d6d166c13edd6c48a4eecb3dbdd11bf92a49395ba953ac31c66a7eb085dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adoptive transfer</topic><topic>Adult</topic><topic>BK virus</topic><topic>BK Virus - pathogenicity</topic><topic>BK Virus - physiology</topic><topic>case report</topic><topic>CliniMACS Prodigy</topic><topic>Cystitis</topic><topic>Cystitis - etiology</topic><topic>Cystitis - immunology</topic><topic>Cystitis - pathology</topic><topic>Cystitis - therapy</topic><topic>donor‐specific T cells</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hemorrhage - etiology</topic><topic>Hemorrhage - immunology</topic><topic>Hemorrhage - pathology</topic><topic>Hemorrhage - therapy</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility Testing</topic><topic>HLA transplantation</topic><topic>Humans</topic><topic>Immunotherapy, Adoptive</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Polyomavirus Infections - etiology</topic><topic>Polyomavirus Infections - immunology</topic><topic>Polyomavirus Infections - pathology</topic><topic>Polyomavirus Infections - therapy</topic><topic>T-Lymphocytes - transplantation</topic><topic>Transplantation</topic><topic>Transplantation, Isogeneic</topic><topic>Treatment Outcome</topic><topic>Tumor Virus Infections - etiology</topic><topic>Tumor Virus Infections - immunology</topic><topic>Tumor Virus Infections - pathology</topic><topic>Tumor Virus Infections - therapy</topic><topic>Viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pello, Oscar M.</creatorcontrib><creatorcontrib>Innes, Andrew J.</creatorcontrib><creatorcontrib>Bradshaw, Anne</creatorcontrib><creatorcontrib>Finn, Sally‐Anne</creatorcontrib><creatorcontrib>Uddin, Shab</creatorcontrib><creatorcontrib>Bray, Emma</creatorcontrib><creatorcontrib>Olavarria, Eduardo</creatorcontrib><creatorcontrib>Apperley, Jane F.</creatorcontrib><creatorcontrib>Pavlů, Jiří</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>European journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pello, Oscar M.</au><au>Innes, Andrew J.</au><au>Bradshaw, Anne</au><au>Finn, Sally‐Anne</au><au>Uddin, Shab</au><au>Bray, Emma</au><au>Olavarria, Eduardo</au><au>Apperley, Jane F.</au><au>Pavlů, Jiří</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BKV‐specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA‐haploidentical haematopoietic cell transplantation</atitle><jtitle>European journal of haematology</jtitle><addtitle>Eur J Haematol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>98</volume><issue>6</issue><spage>632</spage><epage>634</epage><pages>632-634</pages><issn>0902-4441</issn><eissn>1600-0609</eissn><abstract>Background
Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA‐haploidentical transplantation. Adoptive immunotransfer of virus‐specific T cells from the donor is a promising therapeutic approach, although production of these cells is challenging, particularly when dealing with low‐frequency T cells such as BKV‐specific T cells.
Case report
Here, we present a patient who, following haploidentical HCT, developed severe BKV haemorrhagic cystitis, resistant to standard therapy. He responded well to adoptive transfer of donor cells enriched in BKV‐specific T cells using the new second‐generation CliniMACS Prodigy and the Cytokine Capture System from Miltenyi Biotec. Treatment led to full resolution of both the symptoms and viraemia without unwanted complications.
Conclusion
Our observations suggest that use of products enriched with BKV‐specific T cells generated using this system is safe and efficient in HLA‐haploidentical HCT where BKV cystitis can be a serious complication.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28083990</pmid><doi>10.1111/ejh.12848</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-6519-2598</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of haematology, 2017-06, Vol.98 (6), p.632-634 |
| issn | 0902-4441 1600-0609 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adoptive transfer Adult BK virus BK Virus - pathogenicity BK Virus - physiology case report CliniMACS Prodigy Cystitis Cystitis - etiology Cystitis - immunology Cystitis - pathology Cystitis - therapy donor‐specific T cells Hematopoietic Stem Cell Transplantation - adverse effects Hemorrhage - etiology Hemorrhage - immunology Hemorrhage - pathology Hemorrhage - therapy Histocompatibility antigen HLA Histocompatibility Testing HLA transplantation Humans Immunotherapy, Adoptive Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Lymphocytes Lymphocytes T Male Polyomavirus Infections - etiology Polyomavirus Infections - immunology Polyomavirus Infections - pathology Polyomavirus Infections - therapy T-Lymphocytes - transplantation Transplantation Transplantation, Isogeneic Treatment Outcome Tumor Virus Infections - etiology Tumor Virus Infections - immunology Tumor Virus Infections - pathology Tumor Virus Infections - therapy Viremia |
| title | BKV‐specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA‐haploidentical haematopoietic cell transplantation |
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