An immunogenic personal neoantigen vaccine for patients with melanoma

The results of a phase I trial assessing a personal neoantigen multi-peptide vaccine in patients with melanoma, showing feasibility, safety, and immunogenicity. Personalized cancer vaccine trials Neoantigens have long been considered optimal targets for anti-tumour vaccines, and recent mutation codi...

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Veröffentlicht in:	Nature (London) 2017-07, Vol.547 (7662), p.217-221
Hauptverfasser:	Ott, Patrick A., Hu, Zhuting, Keskin, Derin B., Shukla, Sachet A., Sun, Jing, Bozym, David J., Zhang, Wandi, Luoma, Adrienne, Giobbie-Hurder, Anita, Peter, Lauren, Chen, Christina, Olive, Oriol, Carter, Todd A., Li, Shuqiang, Lieb, David J., Eisenhaure, Thomas, Gjini, Evisa, Stevens, Jonathan, Lane, William J., Javeri, Indu, Nellaiappan, Kaliappanadar, Salazar, Andres M., Daley, Heather, Seaman, Michael, Buchbinder, Elizabeth I., Yoon, Charles H., Harden, Maegan, Lennon, Niall, Gabriel, Stacey, Rodig, Scott J., Barouch, Dan H., Aster, Jon C., Getz, Gad, Wucherpfennig, Kai, Neuberg, Donna, Ritz, Jerome, Lander, Eric S., Fritsch, Edward F., Hacohen, Nir, Wu, Catherine J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/21 13/31 13/51 38/23 38/91 631/250/590/2030 631/67/580 Amino Acid Sequence Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use Antigens Antigens, Neoplasm - chemistry Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Apoptosis Cancer treatment Cancer Vaccines - adverse effects Cancer Vaccines - chemistry Cancer Vaccines - immunology Care and treatment CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell death Feasibility studies Gene expression High-Throughput Nucleotide Sequencing Histocompatibility antigen HLA Histocompatibility Antigens Class II - immunology Humanities and Social Sciences Humans Immune checkpoint Immunity Immunogenicity Immunological tolerance Immunotherapy letter Lymphocytes Lymphocytes T Machine Learning Melanoma Melanoma - genetics Melanoma - immunology Melanoma - therapy Methods multidisciplinary Mutation Neoantigens Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - prevention & control Patient Safety Patients PD-1 protein Peptides Precision Medicine - methods Programmed Cell Death 1 Receptor - antagonists & inhibitors Science T cell receptors Thymus Tumors Vaccination Vaccines
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