The biology of JC polyomavirus
JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs in people with underlying immunodeficiency or in individuals being treated with potent immunomodulatory therapies. JCPyV is a D...
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| Veröffentlicht in: | Biological chemistry 2017-07, Vol.398 (8), p.839-855 |
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| container_title | Biological chemistry |
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| creator | Assetta, Benedetta Atwood, Walter J. |
| description | JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs in people with underlying immunodeficiency or in individuals being treated with potent immunomodulatory therapies. JCPyV is a DNA tumor virus with a double-stranded DNA genome and encodes a well-studied oncogene, large T antigen. Its host range is highly restricted to humans and only a few cell types support lytic infection
or
. Its oncogenic potential in humans has not been firmly established and the international committee on oncogenic viruses lists JCPyV as possibly carcinogenic. Significant progress has been made in understanding the biology of JCPyV and here we present an overview of the field and discuss some important questions that remain unanswered. |
| doi_str_mv | 10.1515/hsz-2016-0345 |
| format | Article |
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or
. Its oncogenic potential in humans has not been firmly established and the international committee on oncogenic viruses lists JCPyV as possibly carcinogenic. Significant progress has been made in understanding the biology of JCPyV and here we present an overview of the field and discuss some important questions that remain unanswered.</description><identifier>ISSN: 1431-6730</identifier><identifier>EISSN: 1437-4315</identifier><identifier>DOI: 10.1515/hsz-2016-0345</identifier><identifier>PMID: 28493815</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Animals ; Antigen T (large) ; Biology ; Carcinogens ; Central nervous system ; Demyelination ; Deoxyribonucleic acid ; DNA ; DNA tumor viruses ; Genomes ; Genomics ; HIV/AIDS ; Host range ; Humans ; immune response ; Immunodeficiency ; Immunomodulation ; In vitro methods and tests ; Infections ; JC Virus - genetics ; JC Virus - metabolism ; JC Virus - physiology ; JCPyV ; Leukoencephalopathy ; Lists ; multiple sclerosis ; PML ; Polyomavirus Infections ; Progressive multifocal leukoencephalopathy ; Transcription, Genetic ; Viral Proteins - metabolism ; Virus Physiological Phenomena ; virus receptors ; Viruses</subject><ispartof>Biological chemistry, 2017-07, Vol.398 (8), p.839-855</ispartof><rights>Copyright Walter de Gruyter GmbH 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-bf7341070bc59345ae017a9c9fcc6078cfbf753853b90e1df6f8397a18b311593</citedby><cites>FETCH-LOGICAL-c440t-bf7341070bc59345ae017a9c9fcc6078cfbf753853b90e1df6f8397a18b311593</cites><orcidid>0000-0002-3763-9073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/hsz-2016-0345/pdf$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/hsz-2016-0345/html$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27923,27924,66625,68409</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28493815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Assetta, Benedetta</creatorcontrib><creatorcontrib>Atwood, Walter J.</creatorcontrib><title>The biology of JC polyomavirus</title><title>Biological chemistry</title><addtitle>Biol Chem</addtitle><description>JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs in people with underlying immunodeficiency or in individuals being treated with potent immunomodulatory therapies. JCPyV is a DNA tumor virus with a double-stranded DNA genome and encodes a well-studied oncogene, large T antigen. Its host range is highly restricted to humans and only a few cell types support lytic infection
or
. Its oncogenic potential in humans has not been firmly established and the international committee on oncogenic viruses lists JCPyV as possibly carcinogenic. Significant progress has been made in understanding the biology of JCPyV and here we present an overview of the field and discuss some important questions that remain unanswered.</description><subject>Animals</subject><subject>Antigen T (large)</subject><subject>Biology</subject><subject>Carcinogens</subject><subject>Central nervous system</subject><subject>Demyelination</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA tumor viruses</subject><subject>Genomes</subject><subject>Genomics</subject><subject>HIV/AIDS</subject><subject>Host range</subject><subject>Humans</subject><subject>immune response</subject><subject>Immunodeficiency</subject><subject>Immunomodulation</subject><subject>In vitro methods and tests</subject><subject>Infections</subject><subject>JC Virus - genetics</subject><subject>JC Virus - metabolism</subject><subject>JC Virus - physiology</subject><subject>JCPyV</subject><subject>Leukoencephalopathy</subject><subject>Lists</subject><subject>multiple sclerosis</subject><subject>PML</subject><subject>Polyomavirus Infections</subject><subject>Progressive multifocal leukoencephalopathy</subject><subject>Transcription, Genetic</subject><subject>Viral Proteins - metabolism</subject><subject>Virus Physiological Phenomena</subject><subject>virus receptors</subject><subject>Viruses</subject><issn>1431-6730</issn><issn>1437-4315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkL1PwzAQxS0EoqUwslaRmA13tR3bEguK-FQlljJbSWr3QykudgMKfz0uLYiB6d7wu_fuHiHnCJcoUFzN4ycdAeYUGBcHpI-cScoZisNvjTSXDHrkJMYlACjg7Jj0RoprplD0yXAyt1m18I2fdZl32VORrX3T-VX5vghtPCVHrmyiPdvPAXm5u50UD3T8fP9Y3IxpzTlsaOUk4wgSqlrodEdpAWWpa-3qOgepapcIwZRglQaLU5c7xbQsUVUMMa0MyMXOdx38W2vjxix9G15TpEGNWmCuRipRdEfVwccYrDPrsFiVoTMIZtuGSW2YbRtm20bih3vXtlrZ6S_9834CrnfAR9lsbJjaWWi7JP6k_2uslUr3sy-RjmvB</recordid><startdate>20170726</startdate><enddate>20170726</enddate><creator>Assetta, Benedetta</creator><creator>Atwood, Walter J.</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-3763-9073</orcidid></search><sort><creationdate>20170726</creationdate><title>The biology of JC polyomavirus</title><author>Assetta, Benedetta ; Atwood, Walter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-bf7341070bc59345ae017a9c9fcc6078cfbf753853b90e1df6f8397a18b311593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antigen T (large)</topic><topic>Biology</topic><topic>Carcinogens</topic><topic>Central nervous system</topic><topic>Demyelination</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA tumor viruses</topic><topic>Genomes</topic><topic>Genomics</topic><topic>HIV/AIDS</topic><topic>Host range</topic><topic>Humans</topic><topic>immune response</topic><topic>Immunodeficiency</topic><topic>Immunomodulation</topic><topic>In vitro methods and tests</topic><topic>Infections</topic><topic>JC Virus - genetics</topic><topic>JC Virus - metabolism</topic><topic>JC Virus - physiology</topic><topic>JCPyV</topic><topic>Leukoencephalopathy</topic><topic>Lists</topic><topic>multiple sclerosis</topic><topic>PML</topic><topic>Polyomavirus Infections</topic><topic>Progressive multifocal leukoencephalopathy</topic><topic>Transcription, Genetic</topic><topic>Viral Proteins - metabolism</topic><topic>Virus Physiological Phenomena</topic><topic>virus receptors</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Assetta, Benedetta</creatorcontrib><creatorcontrib>Atwood, Walter J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Assetta, Benedetta</au><au>Atwood, Walter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The biology of JC polyomavirus</atitle><jtitle>Biological chemistry</jtitle><addtitle>Biol Chem</addtitle><date>2017-07-26</date><risdate>2017</risdate><volume>398</volume><issue>8</issue><spage>839</spage><epage>855</epage><pages>839-855</pages><issn>1431-6730</issn><eissn>1437-4315</eissn><abstract>JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). 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or
. Its oncogenic potential in humans has not been firmly established and the international committee on oncogenic viruses lists JCPyV as possibly carcinogenic. Significant progress has been made in understanding the biology of JCPyV and here we present an overview of the field and discuss some important questions that remain unanswered.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>28493815</pmid><doi>10.1515/hsz-2016-0345</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-3763-9073</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological chemistry, 2017-07, Vol.398 (8), p.839-855 |
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| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Animals Antigen T (large) Biology Carcinogens Central nervous system Demyelination Deoxyribonucleic acid DNA DNA tumor viruses Genomes Genomics HIV/AIDS Host range Humans immune response Immunodeficiency Immunomodulation In vitro methods and tests Infections JC Virus - genetics JC Virus - metabolism JC Virus - physiology JCPyV Leukoencephalopathy Lists multiple sclerosis PML Polyomavirus Infections Progressive multifocal leukoencephalopathy Transcription, Genetic Viral Proteins - metabolism Virus Physiological Phenomena virus receptors Viruses |
| title | The biology of JC polyomavirus |
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