Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial

Summary Background Delirium is a common and serious postoperative complication. Subanaesthetic ketamine is often administered intraoperatively for postoperative analgesia, and some evidence suggests that ketamine prevents delirium. The primary purpose of this trial was to assess the effectiveness of...

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Veröffentlicht in:	The Lancet (British edition) 2017-07, Vol.390 (10091), p.267-275
Hauptverfasser:	Avidan, Michael S, Dr Prof, Maybrier, Hannah R, BS, Abdallah, Arbi Ben, PhD, Jacobsohn, Eric, Prof, Vlisides, Phillip E, MD, Pryor, Kane O, MBBS, Veselis, Robert A, Prof, Grocott, Hillary P, Prof, Emmert, Daniel A, MD, Rogers, Emma M, BS, Downey, Robert J, MD, Yulico, Heidi, DNP, Noh, Gyu-Jeong, Prof, Lee, Yonghun H, MD, Waszynski, Christine M, DNP, Arya, Virendra K, Prof, Pagel, Paul S, Prof, Hudetz, Judith A, PhD, Muench, Maxwell R, BS, Fritz, Bradley A, MD, Waberski, Witold, MD, Inouye, Sharon K, Prof, Mashour, George A, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aged Analgesia Analgesics Analgesics - administration & dosage Analgesics - adverse effects Anesthesia Bleeding Central Nervous System Agents - administration & dosage Central Nervous System Agents - adverse effects Clinical medicine Clinical trials Delirium Delirium - prevention & control Double-Blind Method Double-blind studies Drug Administration Schedule Drug dosages Evidence-based medicine Female Hallucinations Heart surgery Humans Internal Medicine Intraoperative Care - methods Ketamine Ketamine - administration & dosage Ketamine - adverse effects Male Mental disorders Middle Aged Older people Pain Pain perception Pain, Postoperative - prevention & control Patients Podcasts Postoperative Complications - prevention & control Postoperative period Prevention Surgery Treatment Outcome
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