Redox Center Modification of Lapachones towards the Synthesis of Nitrogen Heterocycles as Selective Fluorescent Mitochondrial Imaging Probes

We describe herein a synthetic strategy for the synthesis of new fluorescent imidazole and phenazine derivatives synthesized from lapachol, a naturally occurring naphthoquinone isolated from Tabebuia species (ipê tree). The photophysical properties and computational details of these compounds have b...

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Veröffentlicht in:	European journal of organic chemistry 2017-07, Vol.2017 (26), p.3763-3773
Hauptverfasser:	dos Santos, Fabíola S., Dias, Gleiston G., de Freitas, Rossimiriam P., Santos, Lucas S., de Lima, Guilherme F., Duarte, Hélio A., de Simone, Carlos A., Rezende, Lidia M. S. L., Vianna, Monique J. X., Correa, José R., Neto, Brenno A. D., da Silva Júnior, Eufrânio N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Derivatives Fluorescence Heterocycles Imaging Imaging agents Imidazole Markers Mitochondria Permeability Quinones Redox modification Staining Synthesis
Online-Zugang:	Volltext
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