Hepatic vagus nerve regulates Kupffer cell activation via [alpha]7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis

Background Nonalcoholic fatty liver disease ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). Kupffer cells play a central role in promoting hepatic inflammation, which leads to the development of NASH. We investigated the anti-inflammatory effect of hepatic vagus-mediated stimula...

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Veröffentlicht in:	Journal of gastroenterology 2017-08, Vol.52 (8), p.965
Hauptverfasser:	Nishio, Takahiro, Taura, Kojiro, Iwaisako, Keiko, Koyama, Yukinori, Tanabe, Kazutaka, Yamamoto, Gen, Okuda, Yukihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow Bone marrow transplantation Cell activation Choline Fatty liver Inflammation Interleukin 12 Kupffer cells Lipid metabolism Lipopolysaccharides Liver Liver diseases Methionine Monocyte chemoattractant protein Monocyte chemoattractant protein 1 NF-κB protein Nuclear transport Palmitic acid Peroxisome proliferator-activated receptors Phosphorylation Physiological aspects Rodents Saturated fatty acids Steatosis Transplantation Tumor necrosis factor-TNF Tumor necrosis factor-α Vagotomy
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