Astrocyte‐derived lipocalin‐2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia

Lipocalin‐2 (LCN2) has diverse functions in multiple pathophysiological conditions; however, its pathogenic role in vascular dementia (VaD) is unknown. Here, we investigated the role of LCN2 in VaD using rodent models of global cerebral ischemia and hypoperfusion with cognitive impairment and neuroi...

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Veröffentlicht in:	Glia 2017-09, Vol.65 (9), p.1471-1490
Hauptverfasser:	Kim, Jae‐Hong, Ko, Pan‐Woo, Lee, Ho‐Won, Jeong, Ji‐Young, Lee, Maan‐Gee, Kim, Jong‐Heon, Lee, Won‐Ha, Yu, Ri, Oh, Won‐Jong, Suk, Kyoungho
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amnesia Animal models Animals Astrocytes Astrocytes - metabolism Astrocytes - pathology Biomarkers - blood Blood-brain barrier Brain damage Brain injury Carotid arteries Carotid artery Cells, Cultured Cerebral blood flow chronic cerebral hypoperfusion Cognition - physiology Cognitive ability Cognitive Dysfunction - metabolism Cognitive Dysfunction - pathology Death Dementia Dementia disorders Dementia, Vascular - metabolism Dementia, Vascular - pathology Disease Models, Animal Gliosis global cerebral ischemia Hippocampus Hippocampus - blood supply Hippocampus - metabolism Hippocampus - pathology Humans Hypoxia-inducible factor 1a Impairment Inflammation Ischemia Lipocalin Lipocalin-2 - administration & dosage Lipocalin-2 - genetics Lipocalin-2 - metabolism Male Membrane permeability Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - metabolism Microglia - pathology Microvessels - metabolism Microvessels - pathology Mortality neuroinflammation Neuronal-glial interactions Neurons Neurotoxicity Occlusion Patients Permeability Plasma levels Recombinant Proteins - administration & dosage Recombinant Proteins - metabolism Rodents Substantia alba Vascular dementia Vascular Endothelial Growth Factor A - metabolism
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