Maculopapillary analysis in the posterior pole in patients with mild Alzheimer's disease

Purpose To correlate the thickness of focal regions of the macula with those of the peripapillary nerve fiber layer using optical coherence tomography (OCT) in mild Alzheimer's disease (AD) patients and to compare them with age‐matched controls. Methods OCT of the macula and of the optic nerve from 19 mild AD patients and 25 control patients were included in the study. The thickness of 36 macular voxels of the 6 × 6 grid considered for analysis was correlated with the thickness of the 7 temporal papillary wedges across subjects. Each macular voxel was labeled with the peripapillary wedge with the highest correlation using a color‐coded map. Results In comparison with the controls, mild AD patients presented a significant: (i) thinning in the macular voxels 5, 6, 12, 15, 16, 18, 21, and 22 (p