Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity

Inhibitor-1 (I-1) modulates protein phosphatase 1 (PP1) activity and thereby counteracts the phosphorylation by kinases. I-1 is downregulated and deactivated in failing hearts, but whether its role is beneficial or detrimental remains controversial, and opposing therapeutic strategies have been prop...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2017-08, Vol.390 (8), p.857-862
Hauptverfasser:	Neef, Stefan, Heijman, Jordi, Otte, Kristian, Dewenter, Matthias, Saadatmand, Ali R., Meyer-Roxlau, Stefanie, Antos, Christopher L., Backs, Johannes, Dobrev, Dobromir, Wagner, Michael, Maier, Lars S., El-Armouche, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Activation Adrenergic beta-1 Receptor Agonists Animals Biomedical and Life Sciences Biomedicine Brief Communication Ca2+/calmodulin-dependent protein kinase II Calcium-binding protein Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin Cell lines Computer applications Cyclic AMP Dobutamine Dogs Echocardiography, Stress Guanine Nucleotide Exchange Factors - metabolism Heart diseases Inhibition Kinases Mice Mice, Knockout Myocardium - metabolism Myocytes, Cardiac - metabolism Neurosciences Pharmacology/Toxicology Phosphoprotein phosphatase Phosphorylation Protein phosphatase Protein Phosphatase 1 - metabolism Proteins Proteins - genetics Rats Ryanodine Receptor Calcium Release Channel - metabolism Ryanodine receptors Stress, Physiological
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