Diagnostic value of renal perfusion in patients with chronic kidney disease using 3D arterial spin labeling
Purpose To evaluate the diagnostic value of 3D arterial spin labeling (ASL) for noninvasive quantification of renal blood flow (RBF) in patients with chronic kidney disease (CKD). Materials and Methods CKD patients (n = 27) and healthy volunteers (n = 36) underwent renal 3T ASL magnetic resonance im...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2017-08, Vol.46 (2), p.589-594 |
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| creator | Cai, Yu‐zhe Li, Zhi‐cheng Zuo, Pan‐li Pfeuffer, Josef Li, Yu‐ming Liu, Fang Liu, Rong‐bo |
| description | Purpose
To evaluate the diagnostic value of 3D arterial spin labeling (ASL) for noninvasive quantification of renal blood flow (RBF) in patients with chronic kidney disease (CKD).
Materials and Methods
CKD patients (n = 27) and healthy volunteers (n = 36) underwent renal 3T ASL magnetic resonance imaging, with inversion times from 1200 to 2000 msec for volunteers in the preliminary test, and 1800 to 2000 msec for volunteers and CKD patients in the formal experiments. The cortical RBFs were compared, and a correlation between RBF and estimated glomerular filtration rate (eGFR) was evaluated.
Results
For healthy volunteers, RBF values increased with TIs from 1200 to 1600 msec, but were almost constant at TIs from 1600 to 2000 msec. The cortical RBF values of CKD patients were lower than that of healthy volunteers at TIs from 1800 to 2000 msec. In addition, the CKD patients had lower cortical RBF values than the healthy volunteers (P < 0.01 for both), and their RBF values positively correlated with eGFR.
Conclusion
3D ASL is a potential noninvasive method for measuring renal perfusion that can provide valuable information for clinical CKD diagnosis.
Level of Evidence: 1
Technical Efficacy: Stage 3
J. MAGN. RESON. IMAGING 2017;46:589–594 |
| doi_str_mv | 10.1002/jmri.25601 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1918303354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1918303354</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3601-de05c8066ed2088f3ed176d355e8a4aecea5b0e5f6751e8ce5f9ce7e51c478993</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobk5v_AES8E7oTJqlTS9l82MyEUSvQ5aebtm6tCatY__ezE4vvToHznMeeF-ELikZUkLi29XGmWHME0KPUJ_yOI5iLpLjsBPOIipI2kNn3q8IIVk24qeoFwsqKGO8j9YToxa28o3R-EuVLeCqwA6sKnENrmi9qSw2FteqMWAbj7emWWK9dJUNH2uTW9jh3HhQHnCg7QKzCVauAWeCw9fht1RzKMPlHJ0UqvRwcZgD9PFw_z5-imavj9Px3SzSLGSIciBcC5IkkMdEiIJBTtMkZ5yDUCMFGhSfE-BFknIKQoct05ACp3qUiixjA3TdeWtXfbbgG7mqWhcieUkzKhgJyUeBuuko7SrvHRSydmaj3E5SIve9yn2v8qfXAF8dlO18A_kf-ltkAGgHbE0Ju39U8vnlbdpJvwE0zIQf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1918303354</pqid></control><display><type>article</type><title>Diagnostic value of renal perfusion in patients with chronic kidney disease using 3D arterial spin labeling</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Cai, Yu‐zhe ; Li, Zhi‐cheng ; Zuo, Pan‐li ; Pfeuffer, Josef ; Li, Yu‐ming ; Liu, Fang ; Liu, Rong‐bo</creator><creatorcontrib>Cai, Yu‐zhe ; Li, Zhi‐cheng ; Zuo, Pan‐li ; Pfeuffer, Josef ; Li, Yu‐ming ; Liu, Fang ; Liu, Rong‐bo</creatorcontrib><description>Purpose
To evaluate the diagnostic value of 3D arterial spin labeling (ASL) for noninvasive quantification of renal blood flow (RBF) in patients with chronic kidney disease (CKD).
Materials and Methods
CKD patients (n = 27) and healthy volunteers (n = 36) underwent renal 3T ASL magnetic resonance imaging, with inversion times from 1200 to 2000 msec for volunteers in the preliminary test, and 1800 to 2000 msec for volunteers and CKD patients in the formal experiments. The cortical RBFs were compared, and a correlation between RBF and estimated glomerular filtration rate (eGFR) was evaluated.
Results
For healthy volunteers, RBF values increased with TIs from 1200 to 1600 msec, but were almost constant at TIs from 1600 to 2000 msec. The cortical RBF values of CKD patients were lower than that of healthy volunteers at TIs from 1800 to 2000 msec. In addition, the CKD patients had lower cortical RBF values than the healthy volunteers (P < 0.01 for both), and their RBF values positively correlated with eGFR.
Conclusion
3D ASL is a potential noninvasive method for measuring renal perfusion that can provide valuable information for clinical CKD diagnosis.
Level of Evidence: 1
Technical Efficacy: Stage 3
J. MAGN. RESON. IMAGING 2017;46:589–594</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.25601</identifier><identifier>PMID: 28181335</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; arterial spin labeling (ASL) ; Blood flow ; Blood Flow Velocity ; Case-Control Studies ; chronic kidney disease (CKD) ; Correlation ; Diagnosis ; Diagnostic systems ; Epidermal growth factor receptors ; Female ; Glomerular Filtration Rate ; Healthy Volunteers ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Information dissemination ; Kidney - blood supply ; Kidney - diagnostic imaging ; Kidney - physiopathology ; Kidney diseases ; Kidney Failure, Chronic - diagnostic imaging ; Kidney Failure, Chronic - physiopathology ; Kidney transplantation ; Labeling ; Magnetic Resonance Imaging ; magnetic resonance imaging (MRI) ; Male ; Marking ; Middle Aged ; Patients ; Perfusion ; Renal Artery - diagnostic imaging ; renal blood flow (RBF) ; Renal Circulation ; Reproducibility of Results ; Resonance ; Spin labeling ; Spin Labels ; Young Adult</subject><ispartof>Journal of magnetic resonance imaging, 2017-08, Vol.46 (2), p.589-594</ispartof><rights>2017 International Society for Magnetic Resonance in Medicine</rights><rights>2017 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3601-de05c8066ed2088f3ed176d355e8a4aecea5b0e5f6751e8ce5f9ce7e51c478993</citedby><cites>FETCH-LOGICAL-c3601-de05c8066ed2088f3ed176d355e8a4aecea5b0e5f6751e8ce5f9ce7e51c478993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.25601$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.25601$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28181335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Yu‐zhe</creatorcontrib><creatorcontrib>Li, Zhi‐cheng</creatorcontrib><creatorcontrib>Zuo, Pan‐li</creatorcontrib><creatorcontrib>Pfeuffer, Josef</creatorcontrib><creatorcontrib>Li, Yu‐ming</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Liu, Rong‐bo</creatorcontrib><title>Diagnostic value of renal perfusion in patients with chronic kidney disease using 3D arterial spin labeling</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Purpose
To evaluate the diagnostic value of 3D arterial spin labeling (ASL) for noninvasive quantification of renal blood flow (RBF) in patients with chronic kidney disease (CKD).
Materials and Methods
CKD patients (n = 27) and healthy volunteers (n = 36) underwent renal 3T ASL magnetic resonance imaging, with inversion times from 1200 to 2000 msec for volunteers in the preliminary test, and 1800 to 2000 msec for volunteers and CKD patients in the formal experiments. The cortical RBFs were compared, and a correlation between RBF and estimated glomerular filtration rate (eGFR) was evaluated.
Results
For healthy volunteers, RBF values increased with TIs from 1200 to 1600 msec, but were almost constant at TIs from 1600 to 2000 msec. The cortical RBF values of CKD patients were lower than that of healthy volunteers at TIs from 1800 to 2000 msec. In addition, the CKD patients had lower cortical RBF values than the healthy volunteers (P < 0.01 for both), and their RBF values positively correlated with eGFR.
Conclusion
3D ASL is a potential noninvasive method for measuring renal perfusion that can provide valuable information for clinical CKD diagnosis.
Level of Evidence: 1
Technical Efficacy: Stage 3
J. MAGN. RESON. IMAGING 2017;46:589–594</description><subject>Adult</subject><subject>Aged</subject><subject>arterial spin labeling (ASL)</subject><subject>Blood flow</subject><subject>Blood Flow Velocity</subject><subject>Case-Control Studies</subject><subject>chronic kidney disease (CKD)</subject><subject>Correlation</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Information dissemination</subject><subject>Kidney - blood supply</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - diagnostic imaging</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney transplantation</subject><subject>Labeling</subject><subject>Magnetic Resonance Imaging</subject><subject>magnetic resonance imaging (MRI)</subject><subject>Male</subject><subject>Marking</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Renal Artery - diagnostic imaging</subject><subject>renal blood flow (RBF)</subject><subject>Renal Circulation</subject><subject>Reproducibility of Results</subject><subject>Resonance</subject><subject>Spin labeling</subject><subject>Spin Labels</subject><subject>Young Adult</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk5v_AES8E7oTJqlTS9l82MyEUSvQ5aebtm6tCatY__ezE4vvToHznMeeF-ELikZUkLi29XGmWHME0KPUJ_yOI5iLpLjsBPOIipI2kNn3q8IIVk24qeoFwsqKGO8j9YToxa28o3R-EuVLeCqwA6sKnENrmi9qSw2FteqMWAbj7emWWK9dJUNH2uTW9jh3HhQHnCg7QKzCVauAWeCw9fht1RzKMPlHJ0UqvRwcZgD9PFw_z5-imavj9Px3SzSLGSIciBcC5IkkMdEiIJBTtMkZ5yDUCMFGhSfE-BFknIKQoct05ACp3qUiixjA3TdeWtXfbbgG7mqWhcieUkzKhgJyUeBuuko7SrvHRSydmaj3E5SIve9yn2v8qfXAF8dlO18A_kf-ltkAGgHbE0Ju39U8vnlbdpJvwE0zIQf</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Cai, Yu‐zhe</creator><creator>Li, Zhi‐cheng</creator><creator>Zuo, Pan‐li</creator><creator>Pfeuffer, Josef</creator><creator>Li, Yu‐ming</creator><creator>Liu, Fang</creator><creator>Liu, Rong‐bo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>201708</creationdate><title>Diagnostic value of renal perfusion in patients with chronic kidney disease using 3D arterial spin labeling</title><author>Cai, Yu‐zhe ; Li, Zhi‐cheng ; Zuo, Pan‐li ; Pfeuffer, Josef ; Li, Yu‐ming ; Liu, Fang ; Liu, Rong‐bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3601-de05c8066ed2088f3ed176d355e8a4aecea5b0e5f6751e8ce5f9ce7e51c478993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>arterial spin labeling (ASL)</topic><topic>Blood flow</topic><topic>Blood Flow Velocity</topic><topic>Case-Control Studies</topic><topic>chronic kidney disease (CKD)</topic><topic>Correlation</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Epidermal growth factor receptors</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Information dissemination</topic><topic>Kidney - blood supply</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - physiopathology</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - diagnostic imaging</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney transplantation</topic><topic>Labeling</topic><topic>Magnetic Resonance Imaging</topic><topic>magnetic resonance imaging (MRI)</topic><topic>Male</topic><topic>Marking</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Renal Artery - diagnostic imaging</topic><topic>renal blood flow (RBF)</topic><topic>Renal Circulation</topic><topic>Reproducibility of Results</topic><topic>Resonance</topic><topic>Spin labeling</topic><topic>Spin Labels</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Yu‐zhe</creatorcontrib><creatorcontrib>Li, Zhi‐cheng</creatorcontrib><creatorcontrib>Zuo, Pan‐li</creatorcontrib><creatorcontrib>Pfeuffer, Josef</creatorcontrib><creatorcontrib>Li, Yu‐ming</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Liu, Rong‐bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Yu‐zhe</au><au>Li, Zhi‐cheng</au><au>Zuo, Pan‐li</au><au>Pfeuffer, Josef</au><au>Li, Yu‐ming</au><au>Liu, Fang</au><au>Liu, Rong‐bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of renal perfusion in patients with chronic kidney disease using 3D arterial spin labeling</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2017-08</date><risdate>2017</risdate><volume>46</volume><issue>2</issue><spage>589</spage><epage>594</epage><pages>589-594</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To evaluate the diagnostic value of 3D arterial spin labeling (ASL) for noninvasive quantification of renal blood flow (RBF) in patients with chronic kidney disease (CKD).
Materials and Methods
CKD patients (n = 27) and healthy volunteers (n = 36) underwent renal 3T ASL magnetic resonance imaging, with inversion times from 1200 to 2000 msec for volunteers in the preliminary test, and 1800 to 2000 msec for volunteers and CKD patients in the formal experiments. The cortical RBFs were compared, and a correlation between RBF and estimated glomerular filtration rate (eGFR) was evaluated.
Results
For healthy volunteers, RBF values increased with TIs from 1200 to 1600 msec, but were almost constant at TIs from 1600 to 2000 msec. The cortical RBF values of CKD patients were lower than that of healthy volunteers at TIs from 1800 to 2000 msec. In addition, the CKD patients had lower cortical RBF values than the healthy volunteers (P < 0.01 for both), and their RBF values positively correlated with eGFR.
Conclusion
3D ASL is a potential noninvasive method for measuring renal perfusion that can provide valuable information for clinical CKD diagnosis.
Level of Evidence: 1
Technical Efficacy: Stage 3
J. MAGN. RESON. IMAGING 2017;46:589–594</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28181335</pmid><doi>10.1002/jmri.25601</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2017-08, Vol.46 (2), p.589-594 |
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| subjects | Adult Aged arterial spin labeling (ASL) Blood flow Blood Flow Velocity Case-Control Studies chronic kidney disease (CKD) Correlation Diagnosis Diagnostic systems Epidermal growth factor receptors Female Glomerular Filtration Rate Healthy Volunteers Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Information dissemination Kidney - blood supply Kidney - diagnostic imaging Kidney - physiopathology Kidney diseases Kidney Failure, Chronic - diagnostic imaging Kidney Failure, Chronic - physiopathology Kidney transplantation Labeling Magnetic Resonance Imaging magnetic resonance imaging (MRI) Male Marking Middle Aged Patients Perfusion Renal Artery - diagnostic imaging renal blood flow (RBF) Renal Circulation Reproducibility of Results Resonance Spin labeling Spin Labels Young Adult |
| title | Diagnostic value of renal perfusion in patients with chronic kidney disease using 3D arterial spin labeling |
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