Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer

Oxidative/nitrosative stress and endothelial dysfunction are hypothesized to be central to cancer therapeutics–related cardiac dysfunction (CTRCD). However, the relationship between circulating arginine-nitric oxide (NO) metabolites and CTRCD remains unstudied. This study sought to examine the relat...

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Veröffentlicht in:	Journal of the American College of Cardiology 2017-07, Vol.70 (2), p.152-162
Hauptverfasser:	Finkelman, Brian S., Putt, Mary, Wang, Teresa, Wang, Le, Narayan, Hari, Domchek, Susan, DeMichele, Angela, Fox, Kevin, Matro, Jennifer, Shah, Payal, Clark, Amy, Bradbury, Angela, Narayan, Vivek, Carver, Joseph R., Tang, W.H. Wilson, Ky, Bonnie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - therapeutic use Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Arginine Arginine - blood arginine metabolism Bioavailability Biomarkers Biomarkers, Tumor - blood Body mass Body mass index Breast cancer Breast Neoplasms - blood Breast Neoplasms - complications Breast Neoplasms - drug therapy Cancer Cancer therapies cardio-oncology Cardiology Cardiomyocytes Cardiomyopathies - blood Cardiomyopathies - chemically induced Cardiomyopathy cardiotoxicity Cardiovascular disease Chemotherapy Chromatography Citrulline Coronary vessels Doxorubicin Doxorubicin - adverse effects Doxorubicin - therapeutic use Echocardiography Female Follow-Up Studies Heart diseases Heart failure Humans Hypertension Immunotherapy Mass spectrometry Measurement techniques Metabolites Middle Aged Monoclonal antibodies Mortality Nitric oxide Nitric Oxide - blood nitrosative stress Oncology Ornithine Oxidative Stress Patients Plasma levels Prospective Studies Scientific imaging Studies Targeted cancer therapy Time Factors Trastuzumab Trastuzumab - adverse effects Trastuzumab - therapeutic use Ultrasonic imaging
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