Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer
Purpose Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed i...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2017-08, Vol.143 (8), p.1437-1447 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | Ban, Myung Jin Ji, Sang Hee Lee, Chi-Kyu Bae, Sang Byung Kim, Han Jo Ahn, Tae Sung Lee, Moon Soo Baek, Moo-Jun Jeong, Dongjun |
| description | Purpose
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer (CRC). We investigated SLCO4A1 expression, its prognostic value in patients with CRC, and its role in CRC cell proliferation and metastasis.
Methods
SLCO4A1 expression was assessed by immunohistochemistry (IHC) on specimens from 84 patients with CRC. The association of SLCO4A1 expression with clinicopathological features was examined. To confirm the biological role of SLCO4A1 in CRC, four CRC cell lines expressing SLCO4A1 were used and SLCO4A1 expression was knocked down by siRNA. Cell proliferation, MTT, migration, invasion, and semisolid agar colony formation assays were performed.
Results
SLCO4A1 was overexpressed in 32% of the CRC samples. SLCO4A1 overexpression and pathologic T stage were independent prognostic factors of decreased survival (
P
= 0.021). Kaplan–Meier analysis indicated a decreased cumulative survival for patients highly expressing SLCO4A1 compared to patients showing low SLCO4A1 expression (Log-rank test,
P
= 0.025). In cell lines, SLCO4A1 knockdown resulted in a significant decrease of viability, invasion, and migration when compared to control cells. Semisolid colony formation assay indicated that SLCO4A1-knocked down cells presented poor carcinogenic abilities compared to control cells.
Conclusions
SLCO4A1 may be a valuable marker of poor prognostic for CRC. Furthermore, SLCO4A1 plays an important role in CRC cell proliferation, migration, invasion, and carcinogenesis. |
| doi_str_mv | 10.1007/s00432-017-2393-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1917626593</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1917626593</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-cb41b458785464b579fa8c3318ea4a89c28f9695b055eea01c71fb24e50811013</originalsourceid><addsrcrecordid>eNp1UMtOwzAQtBCIlsIHcEGWuMAh4PUjdo5VxUuq1EPhbDnGqVKSuNjJoX-PowLiwsXr3ZmdWQ1Cl0DugBB5HwnhjGYEZEZZwTJ5hKYwToAxcYymCYBMUMgn6CzGLUm9kPQUTahiUpGCTJFf-2boHbYmhNoF7MPGdLXF6fEd7oPp4s6HPiGVaetmj1vXlqnjc8A36-VilT632ERs8C74TedjHXFrwseoVWHrGx-c7U2THDrrwjk6qUwT3cV3naG3x4fXxXO2XD29LObLzDJJ-8yWHEoulFSC57wUsqiMsoyBcoYbVViqqiIvREmEcM4QsBKqknIniAIgwGbo-qCbrvocXOz11g-hS5YaCpA5zUXBEgsOLBt8jMFVehfqdP1eA9FjxPoQsU7J6TFiLdPO1bfyULbu_XfjJ9NEoAdCTFC3ceGP9b-qX_CGhQE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1917626593</pqid></control><display><type>article</type><title>Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Ban, Myung Jin ; Ji, Sang Hee ; Lee, Chi-Kyu ; Bae, Sang Byung ; Kim, Han Jo ; Ahn, Tae Sung ; Lee, Moon Soo ; Baek, Moo-Jun ; Jeong, Dongjun</creator><creatorcontrib>Ban, Myung Jin ; Ji, Sang Hee ; Lee, Chi-Kyu ; Bae, Sang Byung ; Kim, Han Jo ; Ahn, Tae Sung ; Lee, Moon Soo ; Baek, Moo-Jun ; Jeong, Dongjun</creatorcontrib><description>Purpose
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer (CRC). We investigated SLCO4A1 expression, its prognostic value in patients with CRC, and its role in CRC cell proliferation and metastasis.
Methods
SLCO4A1 expression was assessed by immunohistochemistry (IHC) on specimens from 84 patients with CRC. The association of SLCO4A1 expression with clinicopathological features was examined. To confirm the biological role of SLCO4A1 in CRC, four CRC cell lines expressing SLCO4A1 were used and SLCO4A1 expression was knocked down by siRNA. Cell proliferation, MTT, migration, invasion, and semisolid agar colony formation assays were performed.
Results
SLCO4A1 was overexpressed in 32% of the CRC samples. SLCO4A1 overexpression and pathologic T stage were independent prognostic factors of decreased survival (
P
= 0.021). Kaplan–Meier analysis indicated a decreased cumulative survival for patients highly expressing SLCO4A1 compared to patients showing low SLCO4A1 expression (Log-rank test,
P
= 0.025). In cell lines, SLCO4A1 knockdown resulted in a significant decrease of viability, invasion, and migration when compared to control cells. Semisolid colony formation assay indicated that SLCO4A1-knocked down cells presented poor carcinogenic abilities compared to control cells.
Conclusions
SLCO4A1 may be a valuable marker of poor prognostic for CRC. Furthermore, SLCO4A1 plays an important role in CRC cell proliferation, migration, invasion, and carcinogenesis.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-017-2393-7</identifier><identifier>PMID: 28378090</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Agar ; Aged ; Bile salts ; Biomarkers ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - genetics ; Cancer Research ; Carcinogenesis ; Carcinogenesis - genetics ; Carcinogenesis - pathology ; Cell Line, Tumor ; Cell Movement - genetics ; Cell proliferation ; Cell Proliferation - genetics ; Colonies ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Hematology ; Humans ; Immunohistochemistry ; Internal Medicine ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Middle Aged ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; Oncology ; Organic acids ; Organic Anion Transporters - biosynthesis ; Organic Anion Transporters - genetics ; Original Article – Cancer Research ; Prognosis ; Salts ; siRNA ; Survival</subject><ispartof>Journal of cancer research and clinical oncology, 2017-08, Vol.143 (8), p.1437-1447</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>Journal of Cancer Research and Clinical Oncology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-cb41b458785464b579fa8c3318ea4a89c28f9695b055eea01c71fb24e50811013</citedby><cites>FETCH-LOGICAL-c372t-cb41b458785464b579fa8c3318ea4a89c28f9695b055eea01c71fb24e50811013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-017-2393-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-017-2393-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28378090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ban, Myung Jin</creatorcontrib><creatorcontrib>Ji, Sang Hee</creatorcontrib><creatorcontrib>Lee, Chi-Kyu</creatorcontrib><creatorcontrib>Bae, Sang Byung</creatorcontrib><creatorcontrib>Kim, Han Jo</creatorcontrib><creatorcontrib>Ahn, Tae Sung</creatorcontrib><creatorcontrib>Lee, Moon Soo</creatorcontrib><creatorcontrib>Baek, Moo-Jun</creatorcontrib><creatorcontrib>Jeong, Dongjun</creatorcontrib><title>Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer (CRC). We investigated SLCO4A1 expression, its prognostic value in patients with CRC, and its role in CRC cell proliferation and metastasis.
Methods
SLCO4A1 expression was assessed by immunohistochemistry (IHC) on specimens from 84 patients with CRC. The association of SLCO4A1 expression with clinicopathological features was examined. To confirm the biological role of SLCO4A1 in CRC, four CRC cell lines expressing SLCO4A1 were used and SLCO4A1 expression was knocked down by siRNA. Cell proliferation, MTT, migration, invasion, and semisolid agar colony formation assays were performed.
Results
SLCO4A1 was overexpressed in 32% of the CRC samples. SLCO4A1 overexpression and pathologic T stage were independent prognostic factors of decreased survival (
P
= 0.021). Kaplan–Meier analysis indicated a decreased cumulative survival for patients highly expressing SLCO4A1 compared to patients showing low SLCO4A1 expression (Log-rank test,
P
= 0.025). In cell lines, SLCO4A1 knockdown resulted in a significant decrease of viability, invasion, and migration when compared to control cells. Semisolid colony formation assay indicated that SLCO4A1-knocked down cells presented poor carcinogenic abilities compared to control cells.
Conclusions
SLCO4A1 may be a valuable marker of poor prognostic for CRC. Furthermore, SLCO4A1 plays an important role in CRC cell proliferation, migration, invasion, and carcinogenesis.</description><subject>Adult</subject><subject>Agar</subject><subject>Aged</subject><subject>Bile salts</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer Research</subject><subject>Carcinogenesis</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Colonies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Oncology</subject><subject>Organic acids</subject><subject>Organic Anion Transporters - biosynthesis</subject><subject>Organic Anion Transporters - genetics</subject><subject>Original Article – Cancer Research</subject><subject>Prognosis</subject><subject>Salts</subject><subject>siRNA</subject><subject>Survival</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1UMtOwzAQtBCIlsIHcEGWuMAh4PUjdo5VxUuq1EPhbDnGqVKSuNjJoX-PowLiwsXr3ZmdWQ1Cl0DugBB5HwnhjGYEZEZZwTJ5hKYwToAxcYymCYBMUMgn6CzGLUm9kPQUTahiUpGCTJFf-2boHbYmhNoF7MPGdLXF6fEd7oPp4s6HPiGVaetmj1vXlqnjc8A36-VilT632ERs8C74TedjHXFrwseoVWHrGx-c7U2THDrrwjk6qUwT3cV3naG3x4fXxXO2XD29LObLzDJJ-8yWHEoulFSC57wUsqiMsoyBcoYbVViqqiIvREmEcM4QsBKqknIniAIgwGbo-qCbrvocXOz11g-hS5YaCpA5zUXBEgsOLBt8jMFVehfqdP1eA9FjxPoQsU7J6TFiLdPO1bfyULbu_XfjJ9NEoAdCTFC3ceGP9b-qX_CGhQE</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Ban, Myung Jin</creator><creator>Ji, Sang Hee</creator><creator>Lee, Chi-Kyu</creator><creator>Bae, Sang Byung</creator><creator>Kim, Han Jo</creator><creator>Ahn, Tae Sung</creator><creator>Lee, Moon Soo</creator><creator>Baek, Moo-Jun</creator><creator>Jeong, Dongjun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20170801</creationdate><title>Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer</title><author>Ban, Myung Jin ; Ji, Sang Hee ; Lee, Chi-Kyu ; Bae, Sang Byung ; Kim, Han Jo ; Ahn, Tae Sung ; Lee, Moon Soo ; Baek, Moo-Jun ; Jeong, Dongjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-cb41b458785464b579fa8c3318ea4a89c28f9695b055eea01c71fb24e50811013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Agar</topic><topic>Aged</topic><topic>Bile salts</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer Research</topic><topic>Carcinogenesis</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - genetics</topic><topic>Colonies</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Oncology</topic><topic>Organic acids</topic><topic>Organic Anion Transporters - biosynthesis</topic><topic>Organic Anion Transporters - genetics</topic><topic>Original Article – Cancer Research</topic><topic>Prognosis</topic><topic>Salts</topic><topic>siRNA</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ban, Myung Jin</creatorcontrib><creatorcontrib>Ji, Sang Hee</creatorcontrib><creatorcontrib>Lee, Chi-Kyu</creatorcontrib><creatorcontrib>Bae, Sang Byung</creatorcontrib><creatorcontrib>Kim, Han Jo</creatorcontrib><creatorcontrib>Ahn, Tae Sung</creatorcontrib><creatorcontrib>Lee, Moon Soo</creatorcontrib><creatorcontrib>Baek, Moo-Jun</creatorcontrib><creatorcontrib>Jeong, Dongjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ban, Myung Jin</au><au>Ji, Sang Hee</au><au>Lee, Chi-Kyu</au><au>Bae, Sang Byung</au><au>Kim, Han Jo</au><au>Ahn, Tae Sung</au><au>Lee, Moon Soo</au><au>Baek, Moo-Jun</au><au>Jeong, Dongjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>143</volume><issue>8</issue><spage>1437</spage><epage>1447</epage><pages>1437-1447</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer (CRC). We investigated SLCO4A1 expression, its prognostic value in patients with CRC, and its role in CRC cell proliferation and metastasis.
Methods
SLCO4A1 expression was assessed by immunohistochemistry (IHC) on specimens from 84 patients with CRC. The association of SLCO4A1 expression with clinicopathological features was examined. To confirm the biological role of SLCO4A1 in CRC, four CRC cell lines expressing SLCO4A1 were used and SLCO4A1 expression was knocked down by siRNA. Cell proliferation, MTT, migration, invasion, and semisolid agar colony formation assays were performed.
Results
SLCO4A1 was overexpressed in 32% of the CRC samples. SLCO4A1 overexpression and pathologic T stage were independent prognostic factors of decreased survival (
P
= 0.021). Kaplan–Meier analysis indicated a decreased cumulative survival for patients highly expressing SLCO4A1 compared to patients showing low SLCO4A1 expression (Log-rank test,
P
= 0.025). In cell lines, SLCO4A1 knockdown resulted in a significant decrease of viability, invasion, and migration when compared to control cells. Semisolid colony formation assay indicated that SLCO4A1-knocked down cells presented poor carcinogenic abilities compared to control cells.
Conclusions
SLCO4A1 may be a valuable marker of poor prognostic for CRC. Furthermore, SLCO4A1 plays an important role in CRC cell proliferation, migration, invasion, and carcinogenesis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28378090</pmid><doi>10.1007/s00432-017-2393-7</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2017-08, Vol.143 (8), p.1437-1447 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Agar Aged Bile salts Biomarkers Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Cancer Research Carcinogenesis Carcinogenesis - genetics Carcinogenesis - pathology Cell Line, Tumor Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Colonies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Gene expression Gene Expression Regulation, Neoplastic Hematology Humans Immunohistochemistry Internal Medicine Kaplan-Meier Estimate Lymphatic Metastasis Male Medical prognosis Medicine Medicine & Public Health Metastases Middle Aged Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Oncology Organic acids Organic Anion Transporters - biosynthesis Organic Anion Transporters - genetics Original Article – Cancer Research Prognosis Salts siRNA Survival |
| title | Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer |
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