Molecular-genetic properties of Vibrio cholerae El Tor strains circulating in Africa
The review contains some brief information on cholera epidemics in Africa. Comparative analysis of the results of whole-genome sequencing of 30 clinical strains isolated in Africa in different periods of the seventh cholera pandemic (1985–2012) and data from GenBank revealed their great genetic dive...
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| Veröffentlicht in: | Molecular genetics, microbiology and virology microbiology and virology, 2017, Vol.32 (1), p.12-20 |
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| creator | Cheldyshova, N. B. Smirnova, N. I. Zadnova, S. P. Krasnov, Ya. M. Kritsky, A. A. Boiro, M. Y. Kutyrev, V. V. |
| description | The review contains some brief information on cholera epidemics in Africa. Comparative analysis of the results of whole-genome sequencing of 30 clinical strains isolated in Africa in different periods of the seventh cholera pandemic (1985–2012) and data from GenBank revealed their great genetic diversity. It is demonstrated that cholera epidemics in Africa, which began in 1970, were caused for about two decades by typical strains of the pathogen brought from India and Bangladesh. Currently, cholera in Africa is caused by new variants of the pathogen, which originated in Southeast Asia as a result not only of the acquisition of new genes due to horizontal transfer but also alterations in the genomes of previously existing pathogenicity and pandemicity islands. SNP analysis of 53 strains circulating in Africa (30 strains), as well as those isolated in Southeast Asia (23 strains), made it possible to establish phylogenetic relations for the majority of African and Asian strains. The issue of the existence of strains which are apparently endemic for Africa is being discussed. The existing genetic diversity of strains with different levels of virulence and drug resistance indicates the need for continuous molecular monitoring of the causative agent of cholera in Africa. |
| doi_str_mv | 10.3103/S0891416817010025 |
| format | Article |
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Currently, cholera in Africa is caused by new variants of the pathogen, which originated in Southeast Asia as a result not only of the acquisition of new genes due to horizontal transfer but also alterations in the genomes of previously existing pathogenicity and pandemicity islands. SNP analysis of 53 strains circulating in Africa (30 strains), as well as those isolated in Southeast Asia (23 strains), made it possible to establish phylogenetic relations for the majority of African and Asian strains. The issue of the existence of strains which are apparently endemic for Africa is being discussed. The existing genetic diversity of strains with different levels of virulence and drug resistance indicates the need for continuous molecular monitoring of the causative agent of cholera in Africa.</description><identifier>ISSN: 0891-4168</identifier><identifier>ISSN: 0208-0613</identifier><identifier>EISSN: 1934-841X</identifier><identifier>DOI: 10.3103/S0891416817010025</identifier><identifier>PMID: 30561939</identifier><language>eng</language><publisher>New York: Allerton Press</publisher><subject>Biomedical and Life Sciences ; Cholera ; Comparative analysis ; Drug resistance ; Epidemics ; Genetic diversity ; Genomes ; Horizontal transfer ; Life Sciences ; Microbiology ; Molecular Medicine ; Pandemics ; Pathogenicity ; Pathogens ; Phylogeny ; Reviews ; Single-nucleotide polymorphism ; Virulence</subject><ispartof>Molecular genetics, microbiology and virology, 2017, Vol.32 (1), p.12-20</ispartof><rights>Allerton Press, Inc. 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-786324887607527c750e4b7477debe80b11ececc6a03d5689db87479fa50e0213</citedby><cites>FETCH-LOGICAL-c372t-786324887607527c750e4b7477debe80b11ececc6a03d5689db87479fa50e0213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3103/S0891416817010025$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3103/S0891416817010025$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30561939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheldyshova, N. B.</creatorcontrib><creatorcontrib>Smirnova, N. I.</creatorcontrib><creatorcontrib>Zadnova, S. P.</creatorcontrib><creatorcontrib>Krasnov, Ya. M.</creatorcontrib><creatorcontrib>Kritsky, A. A.</creatorcontrib><creatorcontrib>Boiro, M. Y.</creatorcontrib><creatorcontrib>Kutyrev, V. V.</creatorcontrib><title>Molecular-genetic properties of Vibrio cholerae El Tor strains circulating in Africa</title><title>Molecular genetics, microbiology and virology</title><addtitle>Mol. Genet. Microbiol. Virol</addtitle><addtitle>Mol Gen Mikrobiol Virusol</addtitle><description>The review contains some brief information on cholera epidemics in Africa. Comparative analysis of the results of whole-genome sequencing of 30 clinical strains isolated in Africa in different periods of the seventh cholera pandemic (1985–2012) and data from GenBank revealed their great genetic diversity. It is demonstrated that cholera epidemics in Africa, which began in 1970, were caused for about two decades by typical strains of the pathogen brought from India and Bangladesh. Currently, cholera in Africa is caused by new variants of the pathogen, which originated in Southeast Asia as a result not only of the acquisition of new genes due to horizontal transfer but also alterations in the genomes of previously existing pathogenicity and pandemicity islands. SNP analysis of 53 strains circulating in Africa (30 strains), as well as those isolated in Southeast Asia (23 strains), made it possible to establish phylogenetic relations for the majority of African and Asian strains. The issue of the existence of strains which are apparently endemic for Africa is being discussed. The existing genetic diversity of strains with different levels of virulence and drug resistance indicates the need for continuous molecular monitoring of the causative agent of cholera in Africa.</description><subject>Biomedical and Life Sciences</subject><subject>Cholera</subject><subject>Comparative analysis</subject><subject>Drug resistance</subject><subject>Epidemics</subject><subject>Genetic diversity</subject><subject>Genomes</subject><subject>Horizontal transfer</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Molecular Medicine</subject><subject>Pandemics</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Phylogeny</subject><subject>Reviews</subject><subject>Single-nucleotide polymorphism</subject><subject>Virulence</subject><issn>0891-4168</issn><issn>0208-0613</issn><issn>1934-841X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMotlY_gBcJePGymkl2k-yxSP0DFQ9W8bZk09mast2tye7Bb29Kq4jiaQbe770ZHiGnwC4FMHH1xHQOKUgNigFjPNsjQ8hFmugUXvfJcCMnG31AjkJYMpZJLuQhGYi4RTAfktlDW6Pta-OTBTbYOUvXvl2j7xwG2lb0xZXetdS-Rc4bpJOazlpPQ-eNawK1zm_cnWsW1DV0XHlnzTE5qEwd8GQ3R-T5ZjK7vkumj7f31-NpYoXiXaK0FDzVWkmmMq6syhimpUqVmmOJmpUAaNFaaZiYZ1Ln81JHNa9MBBkHMSIX29z48nuPoStWLlisa9Ng24eCQ6Z5mmWxqxE5_4Uu29438bsCcpAqzwXISMGWsr4NwWNVrL1bGf9RACs2lRd_Ko-es11yX65w_u346jgCfAuEKDUL9D9O_5v6CVIviSg</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Cheldyshova, N. B.</creator><creator>Smirnova, N. I.</creator><creator>Zadnova, S. P.</creator><creator>Krasnov, Ya. M.</creator><creator>Kritsky, A. A.</creator><creator>Boiro, M. Y.</creator><creator>Kutyrev, V. V.</creator><general>Allerton Press</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Molecular-genetic properties of Vibrio cholerae El Tor strains circulating in Africa</title><author>Cheldyshova, N. B. ; Smirnova, N. I. ; Zadnova, S. P. ; Krasnov, Ya. M. ; Kritsky, A. A. ; Boiro, M. Y. ; Kutyrev, V. 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Virol</stitle><addtitle>Mol Gen Mikrobiol Virusol</addtitle><date>2017</date><risdate>2017</risdate><volume>32</volume><issue>1</issue><spage>12</spage><epage>20</epage><pages>12-20</pages><issn>0891-4168</issn><issn>0208-0613</issn><eissn>1934-841X</eissn><abstract>The review contains some brief information on cholera epidemics in Africa. Comparative analysis of the results of whole-genome sequencing of 30 clinical strains isolated in Africa in different periods of the seventh cholera pandemic (1985–2012) and data from GenBank revealed their great genetic diversity. It is demonstrated that cholera epidemics in Africa, which began in 1970, were caused for about two decades by typical strains of the pathogen brought from India and Bangladesh. 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| subjects | Biomedical and Life Sciences Cholera Comparative analysis Drug resistance Epidemics Genetic diversity Genomes Horizontal transfer Life Sciences Microbiology Molecular Medicine Pandemics Pathogenicity Pathogens Phylogeny Reviews Single-nucleotide polymorphism Virulence |
| title | Molecular-genetic properties of Vibrio cholerae El Tor strains circulating in Africa |
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