Evaluation of maternal thyroid autoimmune status in gestational trophoblastic disorders

To investigate the maternal autoimmune status of patients with molar pregnancies. The study was conducted at Yuzuncu Yil University, Department of Obstetrics and Gynecology between January 2012 and June 2016. The medical records of patients who were diagnosed and followed for complete and partial molar pregnancies were reviewed retrospectively. The data of patients who were studied for maternal thyroid auto-antibodies including AntiThyroid peroxidase (TPO) and Anti-Tyroglobulin (Tg) were included in the study. The mean maternal age of complete molar pregnancies were significantly higher than partial molar pregnancies (p=0.010). There were no significant differences between two groups in terms of beta-hCG, TSH, and free T4 (p=0.815, p=0.204, and p=0.072, respectively). None of the patients were anti-TPO positive in the study. There was no significant difference in anti-thyroglobulin positivity between the two groups (p=0.950). Maternal thyroid autoantibody status did not show any difference between the partial and complete molar pregnancies. Thyroid dysfunction seen in molar pregnancies seems to be due to the stimulation of follicular cell receptors with hCG rather than auto-antibodies against thyroid gland.