Structural States of ROR[gamma]t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds

The T-cell-specific retinoic acid receptor (RAR)-related orphan receptor-[gamma] (ROR[gamma]t) is a key transcription factor for the production of pro-inflammatory Th17 cytokines, which are implicated in the pathogenesis of autoimmune diseases. Over the years, several structurally diverse ROR[gamma]...

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