Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox‐regulated mechanisms

Epidemiological studies found an increased risk for kidney cancer in hypertensive patients, of which a subgroup has high aldosterone (Ald) levels. We recently showed that Ald is genotoxic both in kidney tubular cells and in rats with mineralocorticoid‐mediated hypertension. The present work investig...

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Veröffentlicht in:	Molecular carcinogenesis 2017-08, Vol.56 (8), p.1868-1883
Hauptverfasser:	Queisser, Nina, Schupp, Nicole, Schwarz, Eva, Hartmann, Christina, Mackenzie, Gerardo G., Oteiza, Patricia I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Activation analysis Aldosterone Aldosterone - metabolism Animals Apoptosis Cancer Cell Line Cell Proliferation Cell survival Cell Transformation, Neoplastic DNA damage Endocrine disorders Enzyme Activation Enzymes ERK1/2 Extracellular signal-regulated kinase Genotoxicity Health risks Humans Hypertension Kidney - metabolism Kidney - pathology Kidney - ultrastructure Kidney cancer Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys Male Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism NAD(P)H oxidase NADPH Oxidases - metabolism Nitric Oxide Synthase - metabolism Nitric-oxide synthase Oxidation-Reduction Oxidative Stress Oxidizing agents Phosphorylation Promotion Rats Rats, Sprague-Dawley Rodents STAT3 Stat3 protein STAT3 Transcription Factor - metabolism Survival
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