Randomized Controlled Trial of Rituximab and Cost‐Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome

Objective To investigate whether rituximab, an anti–B cell therapy, improves symptoms of fatigue and oral dryness in patients with primary Sjögren's syndrome (SS). Methods We conducted a multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group trial that included health economi...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2017-07, Vol.69 (7), p.1440-1450
Hauptverfasser:	Bowman, Simon J., Everett, Colin C., O'Dwyer, John L., Emery, Paul, Pitzalis, Costantino, Ng, Wan‐Fai, Pease, Colin T., Price, Elizabeth J., Sutcliffe, Nurhan, Gendi, Nagui S. T., Hall, Frances C., Ruddock, Sharon P., Fernandez, Catherine, Reynolds, Catherine, Hulme, Claire T., Davies, Kevin A., Edwards, Christopher J., Lanyon, Peter C., Moots, Robert J., Roussou, Euthalia, Giles, Ian P., Sharples, Linda D., Bombardieri, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antirheumatic Agents - economics Antirheumatic Agents - therapeutic use Confidence intervals Corticoids Corticosteroids Cost analysis Cost-Benefit Analysis Double-Blind Method Drugs Economic analysis Fatigue Fatigue - drug therapy Fatigue - etiology Female Humans Immunotherapy Intravenous administration Lymphocytes B Male Middle Aged Monoclonal antibodies Odds Ratio Pain Patient Reported Outcome Measures Patients Quality of Life Quality-Adjusted Life Years Randomization Rituximab Rituximab - economics Rituximab - therapeutic use Sjogren's syndrome Sjogren's Syndrome - complications Sjogren's Syndrome - drug therapy Treatment Outcome United Kingdom Visual Analog Scale Xerostomia - drug therapy Xerostomia - etiology
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