Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines

Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein that functions as an enzyme, cytokine, growth factor and hormone. As a target for oncology, NAMPT is particularly attractive, because it catalyzes the rate-limiting step in the salvage pathway to generate nicotinamide adenine di...

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Veröffentlicht in:	Cardiovascular toxicology 2017-07, Vol.17 (3), p.307-318
Hauptverfasser:	Misner, D. L., Kauss, M. A., Singh, J., Uppal, H., Bruening-Wright, A., Liederer, B. M., Lin, T., McCray, B., La, N., Nguyen, T., Sampath, D., Dragovich, P. S., O’Brien, T., Zabka, T. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animals Assaying Biocompatibility Biomedical and Life Sciences Biomedicine Cardiology Cardiomyocytes Cardiotoxicity Cells Congestive heart failure Cytokines - antagonists & inhibitors Cytokines - metabolism Death Degeneration Dose-Response Relationship, Drug Effusion Embryonic Stem Cells - drug effects Embryonic Stem Cells - enzymology Energy metabolism Enzyme Inhibitors - toxicity Female Heart Heterocyclic Compounds, 2-Ring - toxicity Humans In vitro methods and tests In vivo methods and tests Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - enzymology Inhibition Inhibitors Male Metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Niacinamide Nicotinamide Nicotinamide phosphoribosyltransferase Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors Nicotinamide Phosphoribosyltransferase - metabolism Nicotinic acid Pharmacology Pharmacology/Toxicology Physiological aspects Rankings Rats Rats, Sprague-Dawley Rodents Safety Salvage Species Specificity Sulfones - toxicity Thorax Toxicity
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