Utility of Evaluating an Anticipated Genotyping Thiopurine S-Methyltransferase Polymorphisms before Azathioprine and Mercaptopurine Therapy

Utility of Evaluating an Anticipated Genotyping Thiopurine S-Methyltransferase Polymorphisms before Azathioprine and Mercaptopurine Therapy

Three kinds of patients were analysed: 67 (13.81%) patients that had already experienced thiopurine-induced myelotoxicity before genotyping, 178 (36.70%) that were waiting to undergo genotyping before initiating treatment with azathioprine, 63 (12.99%) studied for adjusting doses and in 177(36.49%)...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e42-e42
Hauptverfasser: Valdez-Acosta, S, González-Rojano, E, Romero-Palacián, D, Hernández, M, Cabaleiro, T, Talegón, M, Abad-Santos, F
Format: Artikel
Sprache:eng
Schlagworte:
6-Mercaptopurine
Azathioprine
Disease control
Genotyping
Internal Medicine
Medical Education
Methyltransferase
Mutation
Myelosuppression
Patients
Studies
Thiopurine S-methyltransferase
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Zusammenfassung:Three kinds of patients were analysed: 67 (13.81%) patients that had already experienced thiopurine-induced myelotoxicity before genotyping, 178 (36.70%) that were waiting to undergo genotyping before initiating treatment with azathioprine, 63 (12.99%) studied for adjusting doses and in 177(36.49%) request there are no data Patients with myelotoxicity showed a higher...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.131