Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer
Purpose To evaluate the dose–volume parameters of the pericardium and heart in order to reduce the risk of radiation-induced pericardial effusion (PE) and symptomatic PE (SPE) in esophageal cancer patients treated with concurrent chemoradiotherapy. Methods In 86 of 303 esophageal cancer patients, fo...
Gespeichert in:
| Veröffentlicht in: | Strahlentherapie und Onkologie 2017-07, Vol.193 (7), p.552-560 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 560 |
|---|---|
| container_issue | 7 |
| container_start_page | 552 |
| container_title | Strahlentherapie und Onkologie |
| container_volume | 193 |
| creator | Ogino, Ichiro Watanabe, Shigenobu Sakamaki, Kentaro Ogino, Yuka Kunisaki, Chikara Kimura, Kazuo |
| description | Purpose
To evaluate the dose–volume parameters of the pericardium and heart in order to reduce the risk of radiation-induced pericardial effusion (PE) and symptomatic PE (SPE) in esophageal cancer patients treated with concurrent chemoradiotherapy.
Methods
In 86 of 303 esophageal cancer patients, follow-up CT was obtained at least 24 months after concurrent chemoradiotherapy. Correlations between clinical factors, including risk factors for cardiac disease, dosimetric factors, and the incidence of PE and SPE after radiotherapy were analyzed using Cox proportional hazard regression analysis. Significant dosimetric factors with the highest hazard ratios were investigated using zones separated according to their distance from esophagus.
Results
PE developed in 49 patients. Univariate analysis showed the mean heart dose, heart V
5
–V
55
, mean pericardium dose, and pericardium V
5
–V
50
to all significantly affect the incidence of PE. Additionally, body surface area was correlated with the incidence of PE in multivariate analysis. Grade 3 and 4 SPE developed in 5 patients. The pericardium V
50
and pericardium D
10
significantly affected the incidence of SPE. The pericardium V
50
in patients with SPE ranged from 17.1 to 21.7%. Factors affecting the incidence of SPE were the V
50
of the pericardium zones within 3 cm and 4 cm of the esophagus.
Conclusion
A wide range of radiation doses to the heart and pericardium were related to the incidence of PE. A pericardium V
50
≤ 17% is important to avoid symptomatic PE in esophageal cancer patients treated with concurrent chemoradiotherapy. |
| doi_str_mv | 10.1007/s00066-017-1127-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1912487812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1912487812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-463088ca0f31b3ca4dcbf4df2334816f8527f06fc65d85502da2300255b0f6e93</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EoqXwAWxQJNaG8SOOs0TlKVViQyV2luNHSdUmwU4W_A3fwpfhKgWxYWVp7pk78kHonMAVASiuIwAIgYEUmBBaYHmApoSzEkNZvh6iaQpKXJBcTtBJjGsAInjJj9GESk655GSKlrdtrLeuD7XJuuBsbfo2xKz1WdC21n3dNrhu7GCczTqXKB3SeJM574eYwqxuvj5dbLs3vXJpbnRjXDhFR15vojvbvzO0vL97mT_ixfPD0_xmgQ1nssdcMJDSaPCMVMxobk3lufWUMS6J8DKnhQfhjcitzHOgVlMGQPO8Ai9cyWbocuztQvs-uNirdTuEJp1UpCTpi4UkNFFkpExoYwzOqy7UWx0-FAG1E6lGkSr5UjuRSqadi33zUG2d_d34MZcAOgIxRc3KhT-n_239Bs0PfwU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1912487812</pqid></control><display><type>article</type><title>Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Ogino, Ichiro ; Watanabe, Shigenobu ; Sakamaki, Kentaro ; Ogino, Yuka ; Kunisaki, Chikara ; Kimura, Kazuo</creator><creatorcontrib>Ogino, Ichiro ; Watanabe, Shigenobu ; Sakamaki, Kentaro ; Ogino, Yuka ; Kunisaki, Chikara ; Kimura, Kazuo</creatorcontrib><description>Purpose
To evaluate the dose–volume parameters of the pericardium and heart in order to reduce the risk of radiation-induced pericardial effusion (PE) and symptomatic PE (SPE) in esophageal cancer patients treated with concurrent chemoradiotherapy.
Methods
In 86 of 303 esophageal cancer patients, follow-up CT was obtained at least 24 months after concurrent chemoradiotherapy. Correlations between clinical factors, including risk factors for cardiac disease, dosimetric factors, and the incidence of PE and SPE after radiotherapy were analyzed using Cox proportional hazard regression analysis. Significant dosimetric factors with the highest hazard ratios were investigated using zones separated according to their distance from esophagus.
Results
PE developed in 49 patients. Univariate analysis showed the mean heart dose, heart V
5
–V
55
, mean pericardium dose, and pericardium V
5
–V
50
to all significantly affect the incidence of PE. Additionally, body surface area was correlated with the incidence of PE in multivariate analysis. Grade 3 and 4 SPE developed in 5 patients. The pericardium V
50
and pericardium D
10
significantly affected the incidence of SPE. The pericardium V
50
in patients with SPE ranged from 17.1 to 21.7%. Factors affecting the incidence of SPE were the V
50
of the pericardium zones within 3 cm and 4 cm of the esophagus.
Conclusion
A wide range of radiation doses to the heart and pericardium were related to the incidence of PE. A pericardium V
50
≤ 17% is important to avoid symptomatic PE in esophageal cancer patients treated with concurrent chemoradiotherapy.</description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-017-1127-8</identifier><identifier>PMID: 28424841</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Cancer ; Chemoradiotherapy ; Correlation analysis ; Dosimetry ; Esophageal cancer ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; Esophagus ; Female ; Heart ; Heart - radiation effects ; Humans ; Incidence ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Oncology ; Original Article ; Patients ; Pericardial Effusion - etiology ; Pericardial Effusion - mortality ; Pericardial Effusion - pathology ; Pericardium ; Pericardium - pathology ; Pericardium - radiation effects ; Proportional Hazards Models ; Quality ; Radiation effects ; Radiation Injuries - etiology ; Radiation Injuries - mortality ; Radiation Injuries - pathology ; Radiation therapy ; Radiometry ; Radiotherapy ; Radiotherapy Dosage ; Regression analysis ; Retrospective Studies ; Risk analysis ; Statistics as Topic ; Surface area ; Survival Rate ; Tomography, X-Ray Computed</subject><ispartof>Strahlentherapie und Onkologie, 2017-07, Vol.193 (7), p.552-560</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>Strahlentherapie und Onkologie is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-463088ca0f31b3ca4dcbf4df2334816f8527f06fc65d85502da2300255b0f6e93</citedby><cites>FETCH-LOGICAL-c438t-463088ca0f31b3ca4dcbf4df2334816f8527f06fc65d85502da2300255b0f6e93</cites><orcidid>0000-0003-0437-8150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00066-017-1127-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00066-017-1127-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28424841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogino, Ichiro</creatorcontrib><creatorcontrib>Watanabe, Shigenobu</creatorcontrib><creatorcontrib>Sakamaki, Kentaro</creatorcontrib><creatorcontrib>Ogino, Yuka</creatorcontrib><creatorcontrib>Kunisaki, Chikara</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><title>Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer</title><title>Strahlentherapie und Onkologie</title><addtitle>Strahlenther Onkol</addtitle><addtitle>Strahlenther Onkol</addtitle><description>Purpose
To evaluate the dose–volume parameters of the pericardium and heart in order to reduce the risk of radiation-induced pericardial effusion (PE) and symptomatic PE (SPE) in esophageal cancer patients treated with concurrent chemoradiotherapy.
Methods
In 86 of 303 esophageal cancer patients, follow-up CT was obtained at least 24 months after concurrent chemoradiotherapy. Correlations between clinical factors, including risk factors for cardiac disease, dosimetric factors, and the incidence of PE and SPE after radiotherapy were analyzed using Cox proportional hazard regression analysis. Significant dosimetric factors with the highest hazard ratios were investigated using zones separated according to their distance from esophagus.
Results
PE developed in 49 patients. Univariate analysis showed the mean heart dose, heart V
5
–V
55
, mean pericardium dose, and pericardium V
5
–V
50
to all significantly affect the incidence of PE. Additionally, body surface area was correlated with the incidence of PE in multivariate analysis. Grade 3 and 4 SPE developed in 5 patients. The pericardium V
50
and pericardium D
10
significantly affected the incidence of SPE. The pericardium V
50
in patients with SPE ranged from 17.1 to 21.7%. Factors affecting the incidence of SPE were the V
50
of the pericardium zones within 3 cm and 4 cm of the esophagus.
Conclusion
A wide range of radiation doses to the heart and pericardium were related to the incidence of PE. A pericardium V
50
≤ 17% is important to avoid symptomatic PE in esophageal cancer patients treated with concurrent chemoradiotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Chemoradiotherapy</subject><subject>Correlation analysis</subject><subject>Dosimetry</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Esophagus</subject><subject>Female</subject><subject>Heart</subject><subject>Heart - radiation effects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pericardial Effusion - etiology</subject><subject>Pericardial Effusion - mortality</subject><subject>Pericardial Effusion - pathology</subject><subject>Pericardium</subject><subject>Pericardium - pathology</subject><subject>Pericardium - radiation effects</subject><subject>Proportional Hazards Models</subject><subject>Quality</subject><subject>Radiation effects</subject><subject>Radiation Injuries - etiology</subject><subject>Radiation Injuries - mortality</subject><subject>Radiation Injuries - pathology</subject><subject>Radiation therapy</subject><subject>Radiometry</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Statistics as Topic</subject><subject>Surface area</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><issn>0179-7158</issn><issn>1439-099X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kMtOwzAQRS0EoqXwAWxQJNaG8SOOs0TlKVViQyV2luNHSdUmwU4W_A3fwpfhKgWxYWVp7pk78kHonMAVASiuIwAIgYEUmBBaYHmApoSzEkNZvh6iaQpKXJBcTtBJjGsAInjJj9GESk655GSKlrdtrLeuD7XJuuBsbfo2xKz1WdC21n3dNrhu7GCczTqXKB3SeJM574eYwqxuvj5dbLs3vXJpbnRjXDhFR15vojvbvzO0vL97mT_ixfPD0_xmgQ1nssdcMJDSaPCMVMxobk3lufWUMS6J8DKnhQfhjcitzHOgVlMGQPO8Ai9cyWbocuztQvs-uNirdTuEJp1UpCTpi4UkNFFkpExoYwzOqy7UWx0-FAG1E6lGkSr5UjuRSqadi33zUG2d_d34MZcAOgIxRc3KhT-n_239Bs0PfwU</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Ogino, Ichiro</creator><creator>Watanabe, Shigenobu</creator><creator>Sakamaki, Kentaro</creator><creator>Ogino, Yuka</creator><creator>Kunisaki, Chikara</creator><creator>Kimura, Kazuo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-0437-8150</orcidid></search><sort><creationdate>20170701</creationdate><title>Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer</title><author>Ogino, Ichiro ; Watanabe, Shigenobu ; Sakamaki, Kentaro ; Ogino, Yuka ; Kunisaki, Chikara ; Kimura, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-463088ca0f31b3ca4dcbf4df2334816f8527f06fc65d85502da2300255b0f6e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Chemoradiotherapy</topic><topic>Correlation analysis</topic><topic>Dosimetry</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Esophagus</topic><topic>Female</topic><topic>Heart</topic><topic>Heart - radiation effects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pericardial Effusion - etiology</topic><topic>Pericardial Effusion - mortality</topic><topic>Pericardial Effusion - pathology</topic><topic>Pericardium</topic><topic>Pericardium - pathology</topic><topic>Pericardium - radiation effects</topic><topic>Proportional Hazards Models</topic><topic>Quality</topic><topic>Radiation effects</topic><topic>Radiation Injuries - etiology</topic><topic>Radiation Injuries - mortality</topic><topic>Radiation Injuries - pathology</topic><topic>Radiation therapy</topic><topic>Radiometry</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Statistics as Topic</topic><topic>Surface area</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogino, Ichiro</creatorcontrib><creatorcontrib>Watanabe, Shigenobu</creatorcontrib><creatorcontrib>Sakamaki, Kentaro</creatorcontrib><creatorcontrib>Ogino, Yuka</creatorcontrib><creatorcontrib>Kunisaki, Chikara</creatorcontrib><creatorcontrib>Kimura, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Strahlentherapie und Onkologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogino, Ichiro</au><au>Watanabe, Shigenobu</au><au>Sakamaki, Kentaro</au><au>Ogino, Yuka</au><au>Kunisaki, Chikara</au><au>Kimura, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer</atitle><jtitle>Strahlentherapie und Onkologie</jtitle><stitle>Strahlenther Onkol</stitle><addtitle>Strahlenther Onkol</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>193</volume><issue>7</issue><spage>552</spage><epage>560</epage><pages>552-560</pages><issn>0179-7158</issn><eissn>1439-099X</eissn><abstract>Purpose
To evaluate the dose–volume parameters of the pericardium and heart in order to reduce the risk of radiation-induced pericardial effusion (PE) and symptomatic PE (SPE) in esophageal cancer patients treated with concurrent chemoradiotherapy.
Methods
In 86 of 303 esophageal cancer patients, follow-up CT was obtained at least 24 months after concurrent chemoradiotherapy. Correlations between clinical factors, including risk factors for cardiac disease, dosimetric factors, and the incidence of PE and SPE after radiotherapy were analyzed using Cox proportional hazard regression analysis. Significant dosimetric factors with the highest hazard ratios were investigated using zones separated according to their distance from esophagus.
Results
PE developed in 49 patients. Univariate analysis showed the mean heart dose, heart V
5
–V
55
, mean pericardium dose, and pericardium V
5
–V
50
to all significantly affect the incidence of PE. Additionally, body surface area was correlated with the incidence of PE in multivariate analysis. Grade 3 and 4 SPE developed in 5 patients. The pericardium V
50
and pericardium D
10
significantly affected the incidence of SPE. The pericardium V
50
in patients with SPE ranged from 17.1 to 21.7%. Factors affecting the incidence of SPE were the V
50
of the pericardium zones within 3 cm and 4 cm of the esophagus.
Conclusion
A wide range of radiation doses to the heart and pericardium were related to the incidence of PE. A pericardium V
50
≤ 17% is important to avoid symptomatic PE in esophageal cancer patients treated with concurrent chemoradiotherapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28424841</pmid><doi>10.1007/s00066-017-1127-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0437-8150</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-7158 |
| ispartof | Strahlentherapie und Onkologie, 2017-07, Vol.193 (7), p.552-560 |
| issn | 0179-7158 1439-099X |
| language | eng |
| recordid | cdi_proquest_journals_1912487812 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Cancer Chemoradiotherapy Correlation analysis Dosimetry Esophageal cancer Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagus Female Heart Heart - radiation effects Humans Incidence Male Medicine Medicine & Public Health Middle Aged Multivariate analysis Oncology Original Article Patients Pericardial Effusion - etiology Pericardial Effusion - mortality Pericardial Effusion - pathology Pericardium Pericardium - pathology Pericardium - radiation effects Proportional Hazards Models Quality Radiation effects Radiation Injuries - etiology Radiation Injuries - mortality Radiation Injuries - pathology Radiation therapy Radiometry Radiotherapy Radiotherapy Dosage Regression analysis Retrospective Studies Risk analysis Statistics as Topic Surface area Survival Rate Tomography, X-Ray Computed |
| title | Dosimetric predictors of radiation-induced pericardial effusion in esophageal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T10%3A06%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dosimetric%20predictors%20of%20radiation-induced%20pericardial%20effusion%20in%C2%A0esophageal%20cancer&rft.jtitle=Strahlentherapie%20und%20Onkologie&rft.au=Ogino,%20Ichiro&rft.date=2017-07-01&rft.volume=193&rft.issue=7&rft.spage=552&rft.epage=560&rft.pages=552-560&rft.issn=0179-7158&rft.eissn=1439-099X&rft_id=info:doi/10.1007/s00066-017-1127-8&rft_dat=%3Cproquest_cross%3E1912487812%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1912487812&rft_id=info:pmid/28424841&rfr_iscdi=true |