Estimation of glomerular filtration rate in cancer patients with abnormal body composition and relation with carboplatin toxicity

Purpose Carboplatin clearance is correlated with glomerular filtration rate (GFR) and usually estimated with creatinine clearance using Cockcroft–Gault (CG) formula. Because plasma creatinine level is highly correlated with muscle mass, we hypothesized that an abnormal body composition with a low le...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2017-07, Vol.80 (1), p.45-53
Hauptverfasser:	Bretagne, M., Jouinot, A., Durand, J. P., Huillard, O., Boudou Rouquette, P., Tlemsani, C., Arrondeau, J., Sarfati, G., Goldwasser, F., Alexandre, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Area Under Curve Body composition Body Composition - physiology Body mass Cancer Cancer Research Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Carboplatin - pharmacokinetics Computed tomography Correlation analysis Creatinine Creatinine - blood Cystatin C Cystatin C - blood Female Glomerular Filtration Rate Health risks Humans Kidneys Lean body mass Male Medicine Medicine & Public Health Middle Aged Neoplasms - drug therapy Neoplasms - pathology Oncology Original Article Paclitaxel Paclitaxel - administration & dosage Patients Pharmacology/Toxicology Prospective Studies Renal insufficiency Risk Thrombocytopenia Thrombocytopenia - chemically induced Thrombocytopenia - epidemiology Toxicity
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