Cover Picture: Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2 (ChemMedChem 12/2017)

The front cover picture shows the process of photocrosslinking a small molecule functionalized with a diaziridino group to its putative target upon UV irradiation, a critical step in photoaffinity chemical proteomics and target deconvolution. Though not intended to reflect the mode of binding, this...

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Veröffentlicht in:	ChemMedChem 2017-06, Vol.12 (12), p.860-860
Hauptverfasser:	Casás‐Selves, Matias, Zhang, Andrew X., Dowling, James E., Hallén, Stefan, Kawatkar, Aarti, Pace, Nicholas J., Denz, Christopher R., Pontz, Timothy, Garahdaghi, Farzin, Cao, Qing, Sabirsh, Alan, Thakur, Kumar, O'Connell, Nichole, Hu, Jun, Cornella‐Taracido, Iván, Weerapana, Eranthie, Zinda, Michael, Goodnow, Robert A., Castaldi, M. Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Ca2+-transporting ATPase chemical biology chemoproteomics Deconvolution Enrichment Irradiation Mass spectrometry Mass spectroscopy Mitochondria Modulation Oxidative phosphorylation Phosphorylation Proteomics target identification Ultraviolet radiation Wnt protein Wnt signaling
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