Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1[beta]-induced thermal hyperalgesia in rats

Summary Aims We previously demonstrated that intrathecal IL-1[beta] upregulated phosphorylation of p38 mitogen-activated protein kinase (P-p38 MAPK) and inducible nitric oxide synthase (iNOS) in microglia and astrocytes in spinal cord, increased nitric oxide (NO) release into cerebrospinal fluid, an...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2017-07, Vol.23 (7), p.580
Hauptverfasser:	Sung, Chun-Sung, Wen, Zhi-Hong, Feng, Chien-Wei, Chen, Chun-Hong, Huang, Shi-Ying, Chen, Nan-Fu, Chen, Wu-Fu, Wong, Chih-Shung
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Astrocytes Cerebrospinal fluid Dizocilpine Glutamatergic transmission Glutamic acid receptors Glutamic acid transporter Hyperalgesia Immunofluorescence Interleukin 1 Kinases MAP kinase Microglia Minocycline N-Methyl-D-aspartic acid receptors Neuronal-glial interactions Nitric oxide Nitric-oxide synthase Pain perception Phosphorylation Potentiation Protein kinase Rodents Spinal cord Western blotting
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