Association of tumor necrosis factor-[alpha] (G-308A) genetic variant with matrix metalloproteinase-9 activity and joint destruction in early rheumatoid arthritis

Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-[alpha] G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial flui...

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Veröffentlicht in:	Clinical rheumatology 2017-07, Vol.36 (7), p.1479
Hauptverfasser:	Stojanovic, Sonja, Stamenkovic, Bojana, Stoimenov, Tatjana Jevtovic, Nedovic, Jovan, Zivkovic, Valentina, Despotovic, Milena, Pavlovic, Dusica
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzyme-linked immunosorbent assay Enzymes FDA approval Gelatinase B Inflammation Matrix metalloproteinase Metalloproteinase Necrosis Osteoarthritis Polymerase chain reaction Radiography Restriction fragment length polymorphism Rheumatoid arthritis Synovial fluid Tumor necrosis factor Tumor necrosis factor-TNF
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