Oral administration of a recombinant cholera toxin B subunit promotes mucosal healing in the colon

Cholera toxin B subunit (CTB) is a component of a licensed oral cholera vaccine. However, CTB has pleiotropic immunomodulatory effects whose impacts on the gut are not fully understood. Here, we found that oral administration in mice of a plant-made recombinant CTB (CTBp) significantly increased sev...

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Veröffentlicht in:	Mucosal immunology 2017-07, Vol.10 (4), p.887-900
Hauptverfasser:	Baldauf, K J, Royal, J M, Kouokam, J C, Haribabu, B, Jala, V R, Yaddanapudi, K, Hamorsky, K T, Dryden, G W, Matoba, N
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/347 631/61/51/1868 692/699/249/2510/257/1389 692/700/565 Administration, Oral Allergology Animals Antibodies Azoxymethane Biomedical and Life Sciences Biomedicine Body weight Body weight loss Caco-2 Cells Cholera Cholera - immunology Cholera - prevention & control Cholera toxin Cholera Toxin - immunology Cholera toxin B subunit Cholera Vaccines - immunology Colitis, Ulcerative - chemically induced Colitis, Ulcerative - complications Colitis, Ulcerative - immunology Colon Colon - pathology Colon cancer Colonic Neoplasms - etiology Colonic Neoplasms - immunology Colonic Neoplasms - prevention & control Colorectal cancer Dextran Dextran Sulfate Disease Models, Animal Epithelium Female Gastroenterology Gene expression Humans Immunology Immunomodulation Inflammatory bowel disease Inflammatory bowel diseases Lamina propria Mice Mice, Inbred C57BL Mucosa Mucous Membrane - immunology Oral administration Quorum sensing Rodents Signal Transduction Small intestine Sodium sulfate Transforming Growth Factor beta - metabolism Tumorigenesis Ulcerative colitis Vaccination Wound Healing
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