Quercetin simultaneously induces G0/G1‐phase arrest and caspase‐mediated crosstalk between apoptosis and autophagy in human leukemia HL‐60 cells

Quercetin is a plant‐derived bioflavonoid with high anticancer activity in various tumors. Herein, the molecular mechanisms by which quercetin exerts its anticancer effects against HL‐60 acute myeloid leukemia (AML) cells were investigated. Results showed that quercetin suppressed cell proliferation...

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Veröffentlicht in:	Environmental toxicology 2017-07, Vol.32 (7), p.1857-1868
Hauptverfasser:	Chang, Junn‐Liang, Chow, Jyh‐Ming, Chang, Jer‐Hwa, Wen, Yu‐Ching, Lin, Yung‐Wei, Yang, Shun‐Fa, Lee, Wei‐Jiunn, Chien, Ming‐Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Acute myeloid leukemia Adenosine diphosphate Anticancer properties Antitumor activity Apoptosis Assaying Autophagy Cancer Caspase cell cycle arrest Cell death Cell proliferation Chains (polymeric) Cleavage Crosstalk Cyclin-dependent kinase Deoxyribonucleic acid DNA DNA fragmentation Fragmentation GTP-binding protein In vitro methods and tests Inhibition Inhibitors Kinases Leukemia Molecular modelling Mortality Myeloid leukemia Organelles Phagocytosis Plant cells Plants Poly(ADP-ribose) polymerase Pretreatment Quercetin Ribose Signal transduction Tumors
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