Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis
Summary Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant a...
Gespeichert in:
| Veröffentlicht in: | Contact dermatitis 2017-07, Vol.77 (1), p.1-16 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 16 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Contact dermatitis |
| container_volume | 77 |
| creator | Koppes, Sjors A. Engebretsen, Kristiane A. Agner, Tove Angelova‐Fischer, Irena Berents, Teresa Brandner, Johanna Brans, Richard Clausen, Maja‐Lisa Hummler, Edith Jakasa, Ivone Jurakić‐Tončic, Ružica John, Swen M. Khnykin, Denis Molin, Sonja Holm, Jan O. Suomela, Sari Thierse, Hermann‐Josef Kezic, Sanja Martin, Stefan F. Thyssen, Jacob P. |
| description | Summary
Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non‐systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described. |
| doi_str_mv | 10.1111/cod.12789 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1909015605</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1909015605</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3889-ce5564358da0e904add317000d5a2ce9c4b13ed8c85f54769a8adb86297995993</originalsourceid><addsrcrecordid>eNp1kD1PwzAQQC0EoqUw8AdQJCaGtOckTuwRhU-pUhcYmCzHdiq3aVzsRFX59RhSuuHlBj-90z2ErjFMcXgzadUUJwVlJ2iMc4AYSJqfojFgIDGmRTpCF96vAHCeJfQcjRKasSIrkjH6KHvndNtF69buGq2WOrJtVBm7EW6tnY9q6yJp207ILvK69aYzX6IzARKtikTTaLc08ogo7TbhuzP-Ep3VovH66jAn6P3p8a18ieeL59fyfh7LlFIWS01InqWEKgGaQSaUSnEBAIqIRGomswqnWlFJSU2yImeCClXRPGEFY4SxdIJuB-_W2c9e-46vbO_asJJjBgwwyUOOCbobKOms907XfOtMuHHPMfCfiDxE5L8RA3tzMPbVRqsj-VctALMB2JlG7_838XLxMCi_AcyWe_A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1909015605</pqid></control><display><type>article</type><title>Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Koppes, Sjors A. ; Engebretsen, Kristiane A. ; Agner, Tove ; Angelova‐Fischer, Irena ; Berents, Teresa ; Brandner, Johanna ; Brans, Richard ; Clausen, Maja‐Lisa ; Hummler, Edith ; Jakasa, Ivone ; Jurakić‐Tončic, Ružica ; John, Swen M. ; Khnykin, Denis ; Molin, Sonja ; Holm, Jan O. ; Suomela, Sari ; Thierse, Hermann‐Josef ; Kezic, Sanja ; Martin, Stefan F. ; Thyssen, Jacob P.</creator><creatorcontrib>Koppes, Sjors A. ; Engebretsen, Kristiane A. ; Agner, Tove ; Angelova‐Fischer, Irena ; Berents, Teresa ; Brandner, Johanna ; Brans, Richard ; Clausen, Maja‐Lisa ; Hummler, Edith ; Jakasa, Ivone ; Jurakić‐Tončic, Ružica ; John, Swen M. ; Khnykin, Denis ; Molin, Sonja ; Holm, Jan O. ; Suomela, Sari ; Thierse, Hermann‐Josef ; Kezic, Sanja ; Martin, Stefan F. ; Thyssen, Jacob P.</creatorcontrib><description>Summary
Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non‐systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.</description><identifier>ISSN: 0105-1873</identifier><identifier>EISSN: 1600-0536</identifier><identifier>DOI: 10.1111/cod.12789</identifier><identifier>PMID: 28497472</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alarmins - analysis ; allergic contact dermatitis ; Antimicrobial Cationic Peptides - analysis ; Antimicrobial peptides ; Atopic dermatitis ; Bioengineering ; Biomarkers ; Biomarkers - analysis ; contact allergy ; Contact dermatitis ; contact sensitization ; Cytokines - analysis ; Dermatitis ; Dermatitis, Allergic Contact - diagnosis ; Eczema ; Epidermis - chemistry ; Genetic diversity ; Genetic Markers ; Humans ; Immunoproteins - analysis ; Inflammation ; Lipids ; Occupational hazards ; Peptide Hydrolases - analysis ; Proteomics ; Tight junctions</subject><ispartof>Contact dermatitis, 2017-07, Vol.77 (1), p.1-16</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-ce5564358da0e904add317000d5a2ce9c4b13ed8c85f54769a8adb86297995993</citedby><cites>FETCH-LOGICAL-c3889-ce5564358da0e904add317000d5a2ce9c4b13ed8c85f54769a8adb86297995993</cites><orcidid>0000-0003-0419-2698 ; 0000-0002-8833-531X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcod.12789$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcod.12789$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28497472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koppes, Sjors A.</creatorcontrib><creatorcontrib>Engebretsen, Kristiane A.</creatorcontrib><creatorcontrib>Agner, Tove</creatorcontrib><creatorcontrib>Angelova‐Fischer, Irena</creatorcontrib><creatorcontrib>Berents, Teresa</creatorcontrib><creatorcontrib>Brandner, Johanna</creatorcontrib><creatorcontrib>Brans, Richard</creatorcontrib><creatorcontrib>Clausen, Maja‐Lisa</creatorcontrib><creatorcontrib>Hummler, Edith</creatorcontrib><creatorcontrib>Jakasa, Ivone</creatorcontrib><creatorcontrib>Jurakić‐Tončic, Ružica</creatorcontrib><creatorcontrib>John, Swen M.</creatorcontrib><creatorcontrib>Khnykin, Denis</creatorcontrib><creatorcontrib>Molin, Sonja</creatorcontrib><creatorcontrib>Holm, Jan O.</creatorcontrib><creatorcontrib>Suomela, Sari</creatorcontrib><creatorcontrib>Thierse, Hermann‐Josef</creatorcontrib><creatorcontrib>Kezic, Sanja</creatorcontrib><creatorcontrib>Martin, Stefan F.</creatorcontrib><creatorcontrib>Thyssen, Jacob P.</creatorcontrib><title>Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis</title><title>Contact dermatitis</title><addtitle>Contact Dermatitis</addtitle><description>Summary
Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non‐systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.</description><subject>Alarmins - analysis</subject><subject>allergic contact dermatitis</subject><subject>Antimicrobial Cationic Peptides - analysis</subject><subject>Antimicrobial peptides</subject><subject>Atopic dermatitis</subject><subject>Bioengineering</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>contact allergy</subject><subject>Contact dermatitis</subject><subject>contact sensitization</subject><subject>Cytokines - analysis</subject><subject>Dermatitis</subject><subject>Dermatitis, Allergic Contact - diagnosis</subject><subject>Eczema</subject><subject>Epidermis - chemistry</subject><subject>Genetic diversity</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Immunoproteins - analysis</subject><subject>Inflammation</subject><subject>Lipids</subject><subject>Occupational hazards</subject><subject>Peptide Hydrolases - analysis</subject><subject>Proteomics</subject><subject>Tight junctions</subject><issn>0105-1873</issn><issn>1600-0536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQQC0EoqUw8AdQJCaGtOckTuwRhU-pUhcYmCzHdiq3aVzsRFX59RhSuuHlBj-90z2ErjFMcXgzadUUJwVlJ2iMc4AYSJqfojFgIDGmRTpCF96vAHCeJfQcjRKasSIrkjH6KHvndNtF69buGq2WOrJtVBm7EW6tnY9q6yJp207ILvK69aYzX6IzARKtikTTaLc08ogo7TbhuzP-Ep3VovH66jAn6P3p8a18ieeL59fyfh7LlFIWS01InqWEKgGaQSaUSnEBAIqIRGomswqnWlFJSU2yImeCClXRPGEFY4SxdIJuB-_W2c9e-46vbO_asJJjBgwwyUOOCbobKOms907XfOtMuHHPMfCfiDxE5L8RA3tzMPbVRqsj-VctALMB2JlG7_838XLxMCi_AcyWe_A</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Koppes, Sjors A.</creator><creator>Engebretsen, Kristiane A.</creator><creator>Agner, Tove</creator><creator>Angelova‐Fischer, Irena</creator><creator>Berents, Teresa</creator><creator>Brandner, Johanna</creator><creator>Brans, Richard</creator><creator>Clausen, Maja‐Lisa</creator><creator>Hummler, Edith</creator><creator>Jakasa, Ivone</creator><creator>Jurakić‐Tončic, Ružica</creator><creator>John, Swen M.</creator><creator>Khnykin, Denis</creator><creator>Molin, Sonja</creator><creator>Holm, Jan O.</creator><creator>Suomela, Sari</creator><creator>Thierse, Hermann‐Josef</creator><creator>Kezic, Sanja</creator><creator>Martin, Stefan F.</creator><creator>Thyssen, Jacob P.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0003-0419-2698</orcidid><orcidid>https://orcid.org/0000-0002-8833-531X</orcidid></search><sort><creationdate>201707</creationdate><title>Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis</title><author>Koppes, Sjors A. ; Engebretsen, Kristiane A. ; Agner, Tove ; Angelova‐Fischer, Irena ; Berents, Teresa ; Brandner, Johanna ; Brans, Richard ; Clausen, Maja‐Lisa ; Hummler, Edith ; Jakasa, Ivone ; Jurakić‐Tončic, Ružica ; John, Swen M. ; Khnykin, Denis ; Molin, Sonja ; Holm, Jan O. ; Suomela, Sari ; Thierse, Hermann‐Josef ; Kezic, Sanja ; Martin, Stefan F. ; Thyssen, Jacob P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-ce5564358da0e904add317000d5a2ce9c4b13ed8c85f54769a8adb86297995993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alarmins - analysis</topic><topic>allergic contact dermatitis</topic><topic>Antimicrobial Cationic Peptides - analysis</topic><topic>Antimicrobial peptides</topic><topic>Atopic dermatitis</topic><topic>Bioengineering</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>contact allergy</topic><topic>Contact dermatitis</topic><topic>contact sensitization</topic><topic>Cytokines - analysis</topic><topic>Dermatitis</topic><topic>Dermatitis, Allergic Contact - diagnosis</topic><topic>Eczema</topic><topic>Epidermis - chemistry</topic><topic>Genetic diversity</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Immunoproteins - analysis</topic><topic>Inflammation</topic><topic>Lipids</topic><topic>Occupational hazards</topic><topic>Peptide Hydrolases - analysis</topic><topic>Proteomics</topic><topic>Tight junctions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koppes, Sjors A.</creatorcontrib><creatorcontrib>Engebretsen, Kristiane A.</creatorcontrib><creatorcontrib>Agner, Tove</creatorcontrib><creatorcontrib>Angelova‐Fischer, Irena</creatorcontrib><creatorcontrib>Berents, Teresa</creatorcontrib><creatorcontrib>Brandner, Johanna</creatorcontrib><creatorcontrib>Brans, Richard</creatorcontrib><creatorcontrib>Clausen, Maja‐Lisa</creatorcontrib><creatorcontrib>Hummler, Edith</creatorcontrib><creatorcontrib>Jakasa, Ivone</creatorcontrib><creatorcontrib>Jurakić‐Tončic, Ružica</creatorcontrib><creatorcontrib>John, Swen M.</creatorcontrib><creatorcontrib>Khnykin, Denis</creatorcontrib><creatorcontrib>Molin, Sonja</creatorcontrib><creatorcontrib>Holm, Jan O.</creatorcontrib><creatorcontrib>Suomela, Sari</creatorcontrib><creatorcontrib>Thierse, Hermann‐Josef</creatorcontrib><creatorcontrib>Kezic, Sanja</creatorcontrib><creatorcontrib>Martin, Stefan F.</creatorcontrib><creatorcontrib>Thyssen, Jacob P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Contact dermatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koppes, Sjors A.</au><au>Engebretsen, Kristiane A.</au><au>Agner, Tove</au><au>Angelova‐Fischer, Irena</au><au>Berents, Teresa</au><au>Brandner, Johanna</au><au>Brans, Richard</au><au>Clausen, Maja‐Lisa</au><au>Hummler, Edith</au><au>Jakasa, Ivone</au><au>Jurakić‐Tončic, Ružica</au><au>John, Swen M.</au><au>Khnykin, Denis</au><au>Molin, Sonja</au><au>Holm, Jan O.</au><au>Suomela, Sari</au><au>Thierse, Hermann‐Josef</au><au>Kezic, Sanja</au><au>Martin, Stefan F.</au><au>Thyssen, Jacob P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>2017-07</date><risdate>2017</risdate><volume>77</volume><issue>1</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><abstract>Summary
Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non‐systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>28497472</pmid><doi>10.1111/cod.12789</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-0419-2698</orcidid><orcidid>https://orcid.org/0000-0002-8833-531X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-1873 |
| ispartof | Contact dermatitis, 2017-07, Vol.77 (1), p.1-16 |
| issn | 0105-1873 1600-0536 |
| language | eng |
| recordid | cdi_proquest_journals_1909015605 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Alarmins - analysis allergic contact dermatitis Antimicrobial Cationic Peptides - analysis Antimicrobial peptides Atopic dermatitis Bioengineering Biomarkers Biomarkers - analysis contact allergy Contact dermatitis contact sensitization Cytokines - analysis Dermatitis Dermatitis, Allergic Contact - diagnosis Eczema Epidermis - chemistry Genetic diversity Genetic Markers Humans Immunoproteins - analysis Inflammation Lipids Occupational hazards Peptide Hydrolases - analysis Proteomics Tight junctions |
| title | Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T14%3A09%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Current%20knowledge%20on%20biomarkers%20for%20contact%20sensitization%20and%20allergic%20contact%20dermatitis&rft.jtitle=Contact%20dermatitis&rft.au=Koppes,%20Sjors%20A.&rft.date=2017-07&rft.volume=77&rft.issue=1&rft.spage=1&rft.epage=16&rft.pages=1-16&rft.issn=0105-1873&rft.eissn=1600-0536&rft_id=info:doi/10.1111/cod.12789&rft_dat=%3Cproquest_cross%3E1909015605%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1909015605&rft_id=info:pmid/28497472&rfr_iscdi=true |