Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy

Despite the high potency of bilirubin as an endogenous anti‐inflammatory compound, its clinical translation has been hampered because of its insolubility in water. Bilirubin‐based nanoparticles that may overcome this critical issue are presented. A polyethylene glycol compound (PEG) was covalently a...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-06, Vol.55 (26), p.7460-7463
Hauptverfasser:	Lee, Yonghyun, Kim, Hyungjun, Kang, Sukmo, Lee, Jinju, Park, Jinho, Jon, Sangyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Administration, Intravenous Animal models Animals Anti-Inflammatory Agents - therapeutic use Bilirubin Bilirubin - therapeutic use Colitis, Ulcerative - therapy Colon Covalence Cytotoxicity Disease Models, Animal Diseases Hydrogen peroxide Inflammation Inflammation - drug therapy inflammation therapy Inflammatory bowel diseases Inflammatory diseases Injection Intravenous administration Mice Nanomedicine Nanoparticles Nanoparticles - therapeutic use Nanotechnology Particle size Polyethylene glycol Polyethylene Glycols - therapeutic use Polyethylenes Scavengers self-assembled nanostructures Therapy Toxicity Ulcerative colitis
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