Role of Aspirin in Breast Cancer Survival
Chemotherapy and hormonal therapy have significantly decreased breast cancer mortality, although with considerable side effects and financial costs. In the USA, over three million women are living after a breast cancer diagnosis and are eager for new treatments that are low in toxicity and cost. Mul...
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| Veröffentlicht in: | Current oncology reports 2017-07, Vol.19 (7), p.48, Article 48 |
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| creator | Chen, Wendy Y. Holmes, Michelle D. |
| description | Chemotherapy and hormonal therapy have significantly decreased breast cancer mortality, although with considerable side effects and financial costs. In the USA, over three million women are living after a breast cancer diagnosis and are eager for new treatments that are low in toxicity and cost. Multiple observational studies have reported improved breast cancer survival with regular aspirin use. Furthermore, pooled data from five large randomized trials of aspirin for cardiovascular disease showed that subjects on aspirin had decreased risk of cancer mortality and decreased risk of metastatic cancer. Although the potential mechanism for aspirin preventing breast cancer is not known, possible pathways may involve platelets, inflammation, cyclooxygenase (COX) 2, hormones, or PI3 kinase. This review article summarizes the current epidemiologic and clinical trial evidence as well as possible underlying mechanisms that justify current phase III randomized trials of aspirin to improve breast cancer survival. |
| doi_str_mv | 10.1007/s11912-017-0605-6 |
| format | Article |
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In the USA, over three million women are living after a breast cancer diagnosis and are eager for new treatments that are low in toxicity and cost. Multiple observational studies have reported improved breast cancer survival with regular aspirin use. Furthermore, pooled data from five large randomized trials of aspirin for cardiovascular disease showed that subjects on aspirin had decreased risk of cancer mortality and decreased risk of metastatic cancer. Although the potential mechanism for aspirin preventing breast cancer is not known, possible pathways may involve platelets, inflammation, cyclooxygenase (COX) 2, hormones, or PI3 kinase. This review article summarizes the current epidemiologic and clinical trial evidence as well as possible underlying mechanisms that justify current phase III randomized trials of aspirin to improve breast cancer survival.</description><identifier>ISSN: 1523-3790</identifier><identifier>EISSN: 1534-6269</identifier><identifier>DOI: 10.1007/s11912-017-0605-6</identifier><identifier>PMID: 28597105</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>1-Phosphatidylinositol 3-kinase ; Aspirin ; Aspirin - therapeutic use ; Breast cancer ; Breast Cancer (B Overmoyer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Cancer therapies ; Chemotherapy ; Clinical trials ; Female ; Health risk assessment ; Humans ; Mammography ; Medicine ; Medicine & Public Health ; Metastases ; Mortality ; Neoplasm Metastasis ; Oncology ; Phosphatidylinositol 3-Kinases - genetics ; Platelets ; Prostaglandin endoperoxide synthase ; Reviews ; Risk Factors ; Section Editor ; Side effects ; Survival ; Survival Analysis ; Topical Collection on Breast Cancer ; Toxicity</subject><ispartof>Current oncology reports, 2017-07, Vol.19 (7), p.48, Article 48</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Current Oncology Reports is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-fac15eda210d1fdcbb3b4e7ba2073e413d9d04bceb9e8a5b34a7930788ffc5e23</citedby><cites>FETCH-LOGICAL-c372t-fac15eda210d1fdcbb3b4e7ba2073e413d9d04bceb9e8a5b34a7930788ffc5e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11912-017-0605-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11912-017-0605-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28597105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Wendy Y.</creatorcontrib><creatorcontrib>Holmes, Michelle D.</creatorcontrib><title>Role of Aspirin in Breast Cancer Survival</title><title>Current oncology reports</title><addtitle>Curr Oncol Rep</addtitle><addtitle>Curr Oncol Rep</addtitle><description>Chemotherapy and hormonal therapy have significantly decreased breast cancer mortality, although with considerable side effects and financial costs. 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Holmes, Michelle D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-fac15eda210d1fdcbb3b4e7ba2073e413d9d04bceb9e8a5b34a7930788ffc5e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Aspirin</topic><topic>Aspirin - therapeutic use</topic><topic>Breast cancer</topic><topic>Breast Cancer (B Overmoyer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Mammography</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Mortality</topic><topic>Neoplasm Metastasis</topic><topic>Oncology</topic><topic>Phosphatidylinositol 3-Kinases - genetics</topic><topic>Platelets</topic><topic>Prostaglandin endoperoxide synthase</topic><topic>Reviews</topic><topic>Risk Factors</topic><topic>Section Editor</topic><topic>Side effects</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Topical Collection on Breast Cancer</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wendy Y.</creatorcontrib><creatorcontrib>Holmes, Michelle D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Current oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wendy Y.</au><au>Holmes, Michelle D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Aspirin in Breast Cancer Survival</atitle><jtitle>Current oncology reports</jtitle><stitle>Curr Oncol Rep</stitle><addtitle>Curr Oncol Rep</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>19</volume><issue>7</issue><spage>48</spage><pages>48-</pages><artnum>48</artnum><issn>1523-3790</issn><eissn>1534-6269</eissn><abstract>Chemotherapy and hormonal therapy have significantly decreased breast cancer mortality, although with considerable side effects and financial costs. In the USA, over three million women are living after a breast cancer diagnosis and are eager for new treatments that are low in toxicity and cost. Multiple observational studies have reported improved breast cancer survival with regular aspirin use. Furthermore, pooled data from five large randomized trials of aspirin for cardiovascular disease showed that subjects on aspirin had decreased risk of cancer mortality and decreased risk of metastatic cancer. Although the potential mechanism for aspirin preventing breast cancer is not known, possible pathways may involve platelets, inflammation, cyclooxygenase (COX) 2, hormones, or PI3 kinase. This review article summarizes the current epidemiologic and clinical trial evidence as well as possible underlying mechanisms that justify current phase III randomized trials of aspirin to improve breast cancer survival.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28597105</pmid><doi>10.1007/s11912-017-0605-6</doi></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase Aspirin Aspirin - therapeutic use Breast cancer Breast Cancer (B Overmoyer Breast Neoplasms - drug therapy Breast Neoplasms - epidemiology Breast Neoplasms - pathology Cancer therapies Chemotherapy Clinical trials Female Health risk assessment Humans Mammography Medicine Medicine & Public Health Metastases Mortality Neoplasm Metastasis Oncology Phosphatidylinositol 3-Kinases - genetics Platelets Prostaglandin endoperoxide synthase Reviews Risk Factors Section Editor Side effects Survival Survival Analysis Topical Collection on Breast Cancer Toxicity |
| title | Role of Aspirin in Breast Cancer Survival |
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