Activation of [alpha]1A-adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing

Background and Purpose A NO-mediated desensitization of vasoconstrictor responses evoked by stimulation of [alpha]1-adrenoceptors has been reported in different vessels. We investigated the involvement of each [alpha]1-adrenoceptor subtype and constitutive NOS isoforms and the influence of ageing an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2017-07, Vol.174 (13), p.2015
Hauptverfasser:	Arce, Cristina, Vicente, Diana, Segura, Vanessa, Flacco, Nicla, Monto, Fermi, Almenar, Luis, Aguero, Jaime, Rueda, Joaquín, Jimenez-Altayo, Francesc, Vila, Elisabet, Noguera, Maria Antonia, D'Ocon, Pilar, Ivorra, Maria Dolores
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Age Aging Aorta Arteries Coronary vessels Desensitization Endothelium Heart diseases Isoforms mRNA NG-Nitroarginine methyl ester Nitric oxide Nitric-oxide synthase Phenylephrine Physiological effects Receptors (physiology) Rodents Vasoconstriction Ventricle Ventricles (cerebral) Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!